Correlation between blood and lymphatic vessel density and results of contrast-enhanced spectral mammography

Elzbieta Luczynska; Joanna Niemiec; Aleksandra Ambicka; Agnieszka Adamczyk; Tomasz Walasek; Janusz Ryś; Beata Sas-Korczyńska

doi:10.5114/pjp.2015.54965

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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3/2015
vol. 66

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abstract:

Original paper

Correlation between blood and lymphatic vessel density and results of contrast-enhanced spectral mammography

Elzbieta Luczynska

,

Joanna Niemiec

,

Aleksandra Ambicka

,

Agnieszka Adamczyk

,

Tomasz Walasek

,

Janusz Ryś

,

Beata Sas-Korczyńska

Pol J Pathol 2015; 66 (3): 310-322

DOI: https://doi.org/10.5114/pjp.2015.54965

Online publish date: 2015/10/23

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Contrast-enhanced spectral mammography (CESM) is a novel technique used for detection of tumour vascularity by imaging the moment in which contrast, delivered to the lesion by blood vessels, leaks out of them, and flows out through lymphatic vessels.

In our study, we included 174 women for whom spectral mammography was performed for diagnostic purposes. The relationship between enhancement in CESM and blood vessel density (BVD), lymphatic vessel density (LVD) or the percentage of fields with at least one lymphatic vessel (distribution of podoplanin-positive vessels – DPV) and other related parameters was assessed in 55 cases. BVD, LVD and DPV were assessed immunohistochemically, applying podoplanin and CD31/CD34 as markers of lymphatic and blood vessels, respectively.

The sensitivity (in detection of malignant lesions) of CESM was 100%, while its specificity – 39%. We found a significant positive correlation between the intensity of enhancement in CESM and BVD (p = 0.007, r = 0.357) and a negative correlation between the intensity of enhancement in CESM and DPV (p = 0.003, r = –0.390). Lesions with the highest enhancement in CESM showed a high number of blood vessels and a low number of lymphatics.

Conclusions: 1) CESM is a method characterized by high sensitivity and acceptable specificity; 2) the correlation between CESM results and blood/lymphatic vessel density confirms its utility in detection of tissue angiogenesis and/or lymphangiogenesis.

keywords:

contrast-enhanced spectral mammography, tissue lymphangiogenesis and/or angiogenesis, normal breast tissue, benign breast disease, invasive breast carcinoma

Correlation between blood and lymphatic vessel density and results of contrast-enhanced spectral mammography

Elzbieta Luczynska , Joanna Niemiec , Aleksandra Ambicka , Agnieszka Adamczyk , Tomasz Walasek , Janusz Ryś , Beata Sas-Korczyńska

contrast-enhanced spectral mammography, tissue lymphangiogenesis and/or angiogenesis, normal breast tissue, benign breast disease, invasive breast carcinoma

Elzbieta Luczynska

,

Joanna Niemiec

,

Aleksandra Ambicka

,

Agnieszka Adamczyk

,

Tomasz Walasek

,

Janusz Ryś

,

Beata Sas-Korczyńska