Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis

Hamid Reza Sadeghi; Ashkan Pirayesh; Shaghayegh Shahsavan; Soroush Amani; Sayed Asadollah Amini; Keyhan Ghatreh Samani; Fatemeh Deris

doi:10.5114/ceji.2020.101251

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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abstract:

Clinical immunology

Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis

Hamid Reza Sadeghi

¹

,

Ashkan Pirayesh

^{1, 2}

,

Shaghayegh Shahsavan

^{1, 2}

,

Soroush Amani

³

,

Sayed Asadollah Amini

⁴

,

Keyhan Ghatreh Samani

⁴

,

Fatemeh Deris

⁵

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Hematopoietic Stem Cell Transplantation and Cell Therapy Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Science, Teheran, Iran
Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Department of Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran

Cent Eur J Immunol 2020; 45 (3): 294-300

DOI: https://doi.org/10.5114/ceji.2020.101251

Online publish date: 2020/11/01

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AMA

Sadeghi H, Pirayesh A, Shahsavan S, et al. Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis. Central European Journal of Immunology. 2020;45(3):294-300. doi:10.5114/ceji.2020.101251.

APA

Sadeghi, H., Pirayesh, A., Shahsavan, S., Amani, S., Amini, S.,  & Samani, K. et al. (2020). Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis. Central European Journal of Immunology, 45(3), 294-300. https://doi.org/10.5114/ceji.2020.101251

Chicago

Sadeghi, Hamid Reza, Ashkan Pirayesh, Shaghayegh Shahsavan, Soroush Amani, Sayed Asadollah Amini, Keyhan Ghatreh Samani,  and Fatemeh Deris. 2020. "Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis". Central European Journal of Immunology 45 (3): 294-300. doi:10.5114/ceji.2020.101251.

Harvard

Sadeghi, H., Pirayesh, A., Shahsavan, S., Amani, S., Amini, S., Samani, K.,  and Deris, F. (2020). Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis. Central European Journal of Immunology, 45(3), pp.294-300. https://doi.org/10.5114/ceji.2020.101251

MLA

Sadeghi, Hamid Reza et al. "Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis." Central European Journal of Immunology, vol. 45, no. 3, 2020, pp. 294-300. doi:10.5114/ceji.2020.101251.

Vancouver

Sadeghi H, Pirayesh A, Shahsavan S, Amani S, Amini S, Samani K et al. Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis. Central European Journal of Immunology. 2020;45(3):294-300. doi:10.5114/ceji.2020.101251.

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Aim of the study
To assess the level of acidic mammalian chitinase (AMCase) expression and IL-8 in nasal inferior turbinate mucosa in patients with mild and moderate to severe allergic rhinitis (AR).

Material and methods
Participants in this case-control study were divided into three groups, including patients with moderate and severe persistent allergic rhinitis, cases with mild forms of persistent AR, and control or healthy group. We obtained biopsies of nasal inferior turbinate mucosa from all participants. Expression of AMCase and IL-8 mRNAs were evaluated by real-time polymerase chain reaction (PCR). The serum levels of AMCase and IL-8 were determined by ELISA. The number of eosinophils per field, blood eosinophils, total serum IgE levels, and specific serum IgE levels were measured. Patients’ clinical manifestations were assessed by total nasal syndrome score (TNSS).

Results
Expression of AMCase and IL-8 in patients with moderate and severe perineal allergic rhinitis were significantly elevated compared to the control group and patients with mild persistent allergic rhinitis. Serum levels of AMCase and IL-8 were associated with specific IgE, nasal eosinophil count, and TNSS.

Conclusions
According to the results of this study, there might be a relationship between the expression of AMCase and IL-8 in nasal turbinate mucosa and the severity of allergic rhinitis.

keywords:

Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis

Hamid Reza Sadeghi 1 , Ashkan Pirayesh 1, 2 , Shaghayegh Shahsavan 1, 2 , Soroush Amani 3 , Sayed Asadollah Amini 4 , Keyhan Ghatreh Samani 4 , Fatemeh Deris 5

allergic rhinitis, AMCase, IL-8, inferior turbinate, nasal mucosa, gene expression

Hamid Reza Sadeghi

¹

,

Ashkan Pirayesh

^{1, 2}

,

Shaghayegh Shahsavan

^{1, 2}

,

Soroush Amani

³

,

Sayed Asadollah Amini

⁴

,

Keyhan Ghatreh Samani

⁴

,

Fatemeh Deris

⁵