Current look at effects of long-term proton pump inhibitors therapy

Barbara Skrzydło-Radomańska

ISSN: 1505-8409

Przewodnik Lekarza/Guide for GPs

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10/2005
vol. 8

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abstract:

Current look at effects of long-term proton pump inhibitors therapy

Barbara Skrzydło-Radomańska

Przew Lek 2005; 10; 52-57

Online publish date: 2005/12/22

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Introduction of proton pump inhibitors (PPI) provided an important progress in treatment of the acid-related diseases. PPI are largely administered andand frequently used in long-term therapy. Hypergastrinaemia induced by PPI may lead in human to enterochromaffin-like cells hyperplasia. No neoplastic changes have been reported after more than a decade of use. Fat and mineral bioavailability remain unaltered by PPI therapy. However absorption and profound acid suppression for many years may lead to vitamin B₁₂ deficiency.

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Current look at effects of long-term proton pump inhibitors therapy

Barbara Skrzydło-Radomańska

proton pump inhibitors, long-term therapy