Current state of knowledge on the use of medical marijuana in some neurological diseases

Cannabinoids are a group of compounds found naturally in animal and plant organisms, and in the human body. Cannabinoids can be extracted from cannabis varieties, differing in morphological structure. In addition to can nabinoids, cannabis contains a number of active compo unds, including terpenes, flavonoids, phenanthrenes, spiroindanes, and dihydrostilbens. Epilepsy, Parkinson’s disease and multiple sclerosis are neurological diseases the symptoms of which dra matically impair patients’ quality of life. If standard pharmacotherapy does not bring the expected results, attempts are made to introduce alternative methods of therapy. One of them is the use of cannabis-based preparations containing two main active substances, i.e. THC and CBD. Preliminary results of clinical trials with cannabis-based preparations indicate a potential therapeutic effect in reducing the frequency of seizures in drug-resistant epilepsy among children. However, this needs to be proven in further properly planned stu dies. In patients with MS, their use may reduce pain and spasticity. In Parkinson’s disease, most of the data on the potential benefits of cannabis-based preparations comes from preclinical studies. The purpose of the studies was to confirm the effecti veness of the use of “medical cannabis.” However, the results of the studies are not clear. On this account, can nabis use is still not a legalised method of therapy in most countries. However, cannabis is more and more often used in severe cases of resistance to treatment. The aim of this paper is to critically analyse contempora ry scientific data on the possible use of medical cannabis.