Cytokines and apoptosis in atopic dermatitis

Łukasz Szymański; Aleksandra Cios; Martyna Ciepielak; Wanda Stankiewicz

doi:10.5114/ada.2019.88394

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Cytokines and apoptosis in atopic dermatitis

Łukasz Szymański

¹

,

Aleksandra Cios

²

,

Martyna Ciepielak

²

,

Wanda Stankiewicz

²

Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Science, Magdalenka, Poland
Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Warsaw, Poland

Adv Dermatol Allergol 2021; XXXVIII (1): 1-13

DOI: https://doi.org/10.5114/ada.2019.88394

Online publish date: 2021/03/11

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Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. AD affects 10–20% of children worldwide and persists into adulthood in a minority of cases, affecting approximately 2–3% of the adult population, with an increased prevalence over the past decades in developed countries. Atopy is a genetic tendency to overproduce IgE class antibodies in response to common antigens found in the environment. Concurrence of different atopy such as allergic rhinitis or asthma in children with AD is estimated at 80%. AD is characterized by a vicious cycle of an allergic immune response. The emerging picture of the AD is a complex disorder with barrier dysfunction, immunological, genetic and environmental factors all playing key roles. Patients with severe or persistent disease and their families experience significant impairment in their quality of life, and in addition, AD places a heavy economic burden on society as a whole. Pathogenesis, the role of the epidermal barrier, mechanisms of cells apoptosis, the role of T cells and cytokines in AD are discussed in this article.

keywords:

Cytokines and apoptosis in atopic dermatitis

Łukasz Szymański 1 , Aleksandra Cios 2 , Martyna Ciepielak 2 , Wanda Stankiewicz 2

atopic dermatitis, apoptosis, cytokines, T cells

Łukasz Szymański

¹

,

Aleksandra Cios

²

,

Martyna Ciepielak

²

,

Wanda Stankiewicz

²