Cytotoxic T lymphocytes could contribute in COVID-19-induced
passing anosmia

Marcin Zaremba; Agnieszka Płusa; Agnieszka Radowicz-Chil

doi:10.5114/ms.2021.109566

eISSN: 2300-6722
ISSN: 1899-1874

Medical Studies/Studia Medyczne

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abstract:

Case report

Cytotoxic T lymphocytes could contribute in COVID-19-induced passing anosmia

Marcin Zaremba

¹

,

Agnieszka Płusa

¹

,

Agnieszka Radowicz-Chil

¹

Department of Clinical and Experimental Pathology, Institute of Medical Sciences, Jan Kochanowski University, Kielce, Poland

Medical Studies/Studia Medyczne 2021; 37 (3): 258–260

DOI: https://doi.org/10.5114/ms.2021.109566

Online publish date: 2021/09/30

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Several clinical reports have demonstrated a spectrum of neurological manifestations of COVID-19 patients with subsequent post-mortem neuropathological findings. The aim of the case description is to show spotty inflammatory lesions in the olfactory bulb, which could lead to passing anosmia. Microscopic examination showed severe ischaemia and microglial proliferation in the olfactory bulb region. We encountered the presence of perivascular infiltration of cytotoxic T lymphocytes (CD8). The COVID-19 pandemic brought us many new challenges concerning viral detection, transmission, abd spread, then clinical symptoms, and clinical outcome. It seems that cytotoxic T response could be a causative factor not only in respiratory tract injury but also is involved in the neural system, but further studies are required.

keywords:

Cytotoxic T lymphocytes could contribute in COVID-19-induced passing anosmia

Marcin Zaremba 1 , Agnieszka Płusa 1 , Agnieszka Radowicz-Chil 1

anosmia, COVID-19, cytotoxic T lymphocytes

Marcin Zaremba

¹

,

Agnieszka Płusa

¹

,

Agnieszka Radowicz-Chil

¹