Toxic agents conjugated to proteins recognizing surface receptors in the treatment of acute myeloid leukemia

Monika Paluszewska

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2001
vol. 5

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abstract:

Toxic agents conjugated to proteins recognizing surface receptors in the treatment of acute myeloid leukemia

Monika Paluszewska

Współcz Onkol (2001) vol. 5, 4 (131-134)

Online publish date: 2003/07/16

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Classical therapy of acute myeloid leukemia remains unsatisfactory. Recent advances in understanding the biology of acute myeloid leukemia have lead to the development of targeted treatment strategies. This review presents the biological properties and therapeutic uses of drugs targeted to surface antigens (monoclonal antibodies, immunotoxins, radioimmunoconjugates and cytokine-toxin fusion proteins). Although the preliminary results with these targeted therapies are promising, further studies are needed to establish their role in the treatment of acute myeloid leukemia.

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Toxic agents conjugated to proteins recognizing surface receptors in the treatment of acute myeloid leukemia

Monika Paluszewska

acute myeloid leukemia, monoclonal antibodies, radioimmunotherapy, immunotoxins