Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations

Magdalena Żychowska; Aleksandra Batycka-Baran; Jacek Szepietowski; Wojciech Baran

doi:10.5114/dr.2016.59141

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2016
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abstract:

Review paper

Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations

Magdalena Żychowska

,

Aleksandra Batycka-Baran

,

Jacek Szepietowski

,

Wojciech Baran

Przegl Dermatol 2016, 103, 176–184

DOI: https://doi.org/10.5114/dr.2016.59141

Online publish date: 2016/05/04

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AMA

Żychowska M, Batycka-Baran A, Szepietowski J, Baran W. Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations. Dermatology Review/Przegląd Dermatologiczny. 2016;103(2):176-184. doi:10.5114/dr.2016.59141.

APA

Żychowska, M., Batycka-Baran, A., Szepietowski, J.,  & Baran, W. (2016). Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations. Dermatology Review/Przegląd Dermatologiczny, 103(2), 176-184. https://doi.org/10.5114/dr.2016.59141

Chicago

Żychowska, Magdalena, Aleksandra Batycka-Baran, Jacek Szepietowski,  and Wojciech Baran. 2016. "Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations". Dermatology Review/Przegląd Dermatologiczny 103 (2): 176-184. doi:10.5114/dr.2016.59141.

Harvard

Żychowska, M., Batycka-Baran, A., Szepietowski, J.,  and Baran, W. (2016). Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations. Dermatology Review/Przegląd Dermatologiczny, 103(2), pp.176-184. https://doi.org/10.5114/dr.2016.59141

MLA

Żychowska, Magdalena et al. "Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations." Dermatology Review/Przegląd Dermatologiczny, vol. 103, no. 2, 2016, pp. 176-184. doi:10.5114/dr.2016.59141.

Vancouver

Żychowska M, Batycka-Baran A, Szepietowski J, Baran W. Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations. Dermatology Review/Przegląd Dermatologiczny. 2016;103(2):176-184. doi:10.5114/dr.2016.59141.

PlumX metrics:

Dapsone has been used in the treatment of bullous pemphigoid (BP) for over 50 years. According to the 2015 European Recommendations, the treatment of choice in BP are potent topical corticosteroids. In this article, we present data from the literature on the mechanism of action, efficacy and safety of dapsone in BP. After an extensive search of the PubMed database, we identified one systemic review and 7 nonrandomized clinical trials assessing the efficacy of dapson in BP. Data from the literature indicate that monotherapy with dapsone may be effective in 20–45.4% of BP cases. Combined treatment with dapsone and topical potent corticosteroids increases the efficacy up to 63–76%. The combination of oral corticosteroids and dapsone induces remission in 92–100% of cases. According to many authors, dapsone may be an effective and safe corticosteroid-sparing drug. Still there is a need for randomized controlled trials assessing the effectiveness of different treatment options in BP cases.

keywords:

Dapsone – mechanism of action, safety of use and the role in the treatment of bullous pemphigoid according to current recommendations

Magdalena Żychowska , Aleksandra Batycka-Baran , Jacek Szepietowski , Wojciech Baran

glucocorticoid therapy, bullous pemphigoid (BP), dapsone

Magdalena Żychowska

,

Aleksandra Batycka-Baran

,

Jacek Szepietowski

,

Wojciech Baran