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ISSN: 1233-9687
Polish Journal of Pathology
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3/2016
vol. 67
 
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abstract:
Case report

Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall

Jiri Soukup
1
,
Dimitar Hadzi-Nikolov
1
,
Ales Ryska
1

  1. The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic
Pol J Pathol 2016; 67 (3): 291-294
DOI: https://doi.org/10.5114/pjp.2016.63782
Online publish date: 2016/11/25
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Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Immunohistochemical analysis with antibodies against CD31, CD56, CD68, CD117, S-100 protein, inhibin, calretinin, EMA, p53 and MIB-1 was performed, showing expression of CD56, CD68, S-100 protein, inhibin and calretinin. The diagnosis of atypical dermatofibroma-like GCT was made.
keywords:

granular cell tumour, soft tissue tumours, S100
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