Detection of androgen receptor Exon 1 CAG trinucleotide polymorphism as a diagnostic method of hormone-related dysfunctions

Artur Chełmicki; Piotr Lewandowski; Zbigniew Chełmicki

ISSN: 1231-6407

Ginekologia Praktyczna - - - ARCHIVAL

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3/2004
vol. 12

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abstract:

Detection of androgen receptor Exon 1 CAG trinucleotide polymorphism as a diagnostic method of hormone-related dysfunctions

Artur Chełmicki

,

Piotr Lewandowski

,

Zbigniew Chełmicki

Gin Prakt 2004, 12, 3, 36-39

Online publish date: 2004/06/25

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The human androgen receptor gene contains polymorphic CAG region in first exon. Androgen receptor activity increases or decreases in correspondence to CAG length. This leads to various pathological states including neuro-muscular diseases, androgen related diseases, and carcinomas. Molecular biology as a scientific branch develops constantly, therefore number of studies using its techniques rapidly increases. In this paper we concentrated on most recent studies on androgen receptor gene polymorphism especially in relation with detection of estrogen dependent cancers such as breast cancer, ovarian cancer or endometrial cancer. Clinical value of this method is very promising, but further studies are needed.

keywords:

Detection of androgen receptor Exon 1 CAG trinucleotide polymorphism as a diagnostic method of hormone-related dysfunctions

Artur Chełmicki , Piotr Lewandowski , Zbigniew Chełmicki

androgens, androgen receptor, CAG polymorphism, breast cancer, ovarian cancer, endometrial cancer, androgen insensivity syndrome

Artur Chełmicki

,

Piotr Lewandowski

,

Zbigniew Chełmicki