Determination of butyric acid dosage based on clinical and experimental studies – a literature review

Tomasz Banasiewicz; Dorota Domagalska; Katarzyna Borycka-Kiciak; Grażyna Rydzewska

doi:10.5114/pg.2020.95556

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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2/2020
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abstract:

Review paper

Determination of butyric acid dosage based on clinical and experimental studies – a literature review

Tomasz Banasiewicz

¹

,

Dorota Domagalska

¹

,

Katarzyna Borycka-Kiciak

²

,

Grażyna Rydzewska

^{3, 4}

Chair and Clinic of General and Endocrine Surgery and of Gastrointestinal Oncology, Poznan University of Medical Sciences, Poznan, Poland
Clinic of General and Colorectal Surgery, Centre of Postgraduate Medical Education, Bielanski Hospital, Warsaw, Poland
Clinic of Internal Diseases and Gastroenterology, Central Teaching Hospital of the Ministry of Interior and Administration (MSWiA), Warsaw, Poland
Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland

Gastroenterology Rev 2020; 15 (2): 119–125

DOI: https://doi.org/10.5114/pg.2020.95556

Online publish date: 2020/06/08

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Short-chain fatty acids produced by bacteria living in the large intestine are the main energy substrate for the colonocytes. Butyric acid is used for the treatment and prevention of exacerbations of various gastrointestinal diseases: diarrhoea, intestinal inflammations, functional disorders, dysbiosis, and post-surgery or post-chemotherapy conditions. The current standard doses of butyric acid (150–300 mg) range between 1.5–3% and 15–30% of the reported daily demand. Increased metabolism of the colonocytes in conditions involving intestine damage or inflammation, increased energy expenditure during a disease, stimulation of intestine growth in ‘stress’ conditions with accelerated intestinal passage and increased intestinal excretion, and decreased production of endogenous butyrate due to changes in bacterial flora in different pathological conditions require a significant increase of the supply of this acid. Physiological high demand for butyrate and known mechanisms of pathological conditions indicate that current supplementation doses do not cover the demand and their increase should be considered.

keywords:

Determination of butyric acid dosage based on clinical and experimental studies – a literature review

Tomasz Banasiewicz 1 , Dorota Domagalska 1 , Katarzyna Borycka-Kiciak 2 , Grażyna Rydzewska 3, 4

butyrate, irritable bowel syndrome, dosage, short-chain fatty acids

Tomasz Banasiewicz

¹

,

Dorota Domagalska

¹

,

Katarzyna Borycka-Kiciak

²

,

Grażyna Rydzewska

^{3, 4}