Current issue
Archive
About the journal
Editorial board
Abstracting and indexing
Subscription
Contact
Instructions for authors
Publication charge
Ethical standards and procedures
Editorial System
Submit your Manuscript
|
4/2014
vol. 95 abstract:
Short communication
Development of hammerhead ribozymes targeting miR-21
Agnieszka Belter
,
Mirosława Zofia Naskręt-Barciszewska
vol. 95(4) C pp. 267-271 C 2014
Online publish date: 2015/12/21
View
full text
Get citation
ENW EndNote
BIB JabRef, Mendeley
RIS Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
The object of the invention are hammerhead ribozymes directed against the sequence of miR-21 and /or miR-21 precursors, having the ability to specifically cleave miR-21 and /or miR- 21 precursors, and wherein they have acatalytic core with a sequence as shown in SEQ ID No 1. The invention also relates to a composition comprising such ribozymes, a therapeutic agent comprising them, a use of such ribozymes and a method of selective cleavage of miR-21 and /or 1 miR-21 precursors employing such ribozymes.
|