eISSN: 2353-9461
ISSN: 0860-7796
BioTechnologia
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4/2014
vol. 95
 
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abstract:
Short communication

Development of hammerhead ribozymes targeting miR-21

Agnieszka Belter
,
Mirosława Zofia Naskręt-Barciszewska

vol. 95(4) C pp. 267-271 C 2014
Online publish date: 2015/12/21
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The object of the invention are hammerhead ribozymes directed against the sequence of miR-21 and /or miR-21 precursors, having the ability to specifically cleave miR-21 and /or miR- 21 precursors, and wherein they have acatalytic core with a sequence as shown in SEQ ID No 1. The invention also relates to a composition comprising such ribozymes, a therapeutic agent comprising them, a use of such ribozymes and a method of selective cleavage of miR-21 and /or 1 miR-21 precursors employing such ribozymes.


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