eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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1/2024
vol. 19
 
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abstract:
Original paper

Diagnostic value of apparent diffusion coefficient of psoas muscles for evaluating complications in patients with Crohn’s disease

Bohdan Melekh
1
,
Felix Barajas Ordonez
2
,
Oksana Melekh
1
,
Wiebke Flintrop
3
,
Maciej Pech
1
,
Alexey Surov
4

  1. University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany
  2. Department of Diagnostic and Interventional Radiology, University Hospital RWTH, Aachen, Germany
  3. Department of Paediatrics, University Hospital Magdeburg, Magdeburg, Germany
  4. Institute for Radiology, Neuroradiology and Nuclear Medicine, Johannes Wesling University Hospital by Muehlenkreiskliniken, Ruhr University Bochum, Minden, Germany
Gastroenterology Rev 2024; 19 (1): 74–80
DOI: https://doi.org/10.5114/pg.2024.134519
Online publish date: 2024/01/22
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Aim
To assess the association of the apparent diffusion coefficient (ADC) of the psoas muscles and psoas muscle index (PMI) with the activity and behaviour of Crohn’s disease (CD).

Material and methods
This was a retrospective study of 88 CD patients who underwent magnetic resonance enterography. Patients were classified according to the Montreal Classification in uncomplicated (non-stricturing, non-penetrating, B1), and complicated (structuring [B2] and penetrating disease [B3]). At the level of the third lumbar vertebra, the ADC and PMI were estimated. CD activity was analysed using the Magnetic Resonance Index of Activity (MaRIA), and depending on its values patients were categorized as high or low activity. Additionally, the presence of creeping fat (CrF) was used to evaluate activity. ADC and PMI were using Student’s t-test.

Results
Our study included 47 males and 41 females (mean age of 38.69 ±14.4 years). The ADC in uncomplicated (B1, n = 45) and complicated disease (B2 + B3, n = 43) were 1.11 ±0.19 and 1.03 ±0.10 (10–3*mm2/s), respectively, (p = 0.02). ADC was significantly lower in patients with stricturing disease than in patients without strictures (1.02 ±0.11 and 1.10 ±0.18 [10–3 mm2/s], respectively, p = 0.01). The group with non-penetrating disease showed higher PMI than those with penetrating disease (5.71 ±1.88 vs. 4.42 ±1.55 cm2/m2, respectively, p = 0.10). There was no significant difference in PMI and ADC between patients with low and high MaRIA or positive and negative CrF.

Conclusions
The ADC of the psoas muscles is significantly lower in CD patients with uncomplicated disease, particularly those with stricturing disease. Therefore, ADC can be considered as an imaging biomarker of myopathic changes in CD patients.

keywords:

disease, magnetic resonance imaging, diffusion-weighted imaging, apparent diffusion coefficient
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