Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?

Catalin Pricop; Dragomir Șerban; Ionela Șerban; Alin Cumpanas; Dragoș Puia

doi:10.5114/wiitm.2020.92307

eISSN: 2299-0054
ISSN: 1895-4588

Videosurgery and Other Miniinvasive Techniques

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abstract:

Original paper

Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?

Catalin Pricop

¹

,

Dragomir Nicolae Șerban

²

,

Ionela Lacramioara Șerban

²

,

Alin Adrian Cumpanas

³

,

Dragoș Puia

¹

Department of Urology, “Gr. T. Popa” University of Medicine and Pharmacy, “C. I. Parhon” Hospital, Iasi, Romania
Department of Physiology, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Department of Urology, Victor Babeș University of Medicine and Pharmacy, Timisoara, Romania

Videosurgery Miniinv 2020; 15 (4): 602–607

DOI: https://doi.org/10.5114/wiitm.2020.92307

Online publish date: 2020/01/16

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AMA

Pricop C, Șerban DN, Șerban IL, Cumpanas AA, Puia D. Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?. Videosurgery and Other Miniinvasive Techniques. 2020:602-607. doi:10.5114/wiitm.2020.92307.

APA

Pricop, C., Șerban, D. N., Șerban, I. L., Cumpanas, A. A.,  & Puia, D. (2020). Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?. Videosurgery and Other Miniinvasive Techniques, 602-607. https://doi.org/10.5114/wiitm.2020.92307

Chicago

Pricop, Catalin, Dragomir N Șerban, Ionela L Șerban, Alin A Cumpanas,  and Dragoș Puia. 2020. "Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?". Videosurgery and Other Miniinvasive Techniques: 602-607. doi:10.5114/wiitm.2020.92307.

Harvard

Pricop, C., Șerban, D., Șerban, I., Cumpanas, A.,  and Puia, D. (2020). Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?. Videosurgery and Other Miniinvasive Techniques, pp.602-607. https://doi.org/10.5114/wiitm.2020.92307

MLA

Pricop, Catalin et al. "Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?." Videosurgery and Other Miniinvasive Techniques, 2020, pp. 602-607. doi:10.5114/wiitm.2020.92307.

Vancouver

Pricop C, Șerban D, Șerban I, Cumpanas A, Puia D. Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?. Videosurgery and Other Miniinvasive Techniques. 2020:602-607. doi:10.5114/wiitm.2020.92307.

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Introduction
Different antagonists of αadrenergic receptors (α-blockers) have been used as medical expulsive treatment (MET) after extracorporeal shock wave lithotripsy (ESWL).

Aim
To retrospectively evaluate the expulsion rate of fragments after extracorporeal shock wave lithotripsy performed for single ureteral stones followed by different medical expulsive treatments.

Material and methods
We retrospectively analyzed stone expulsion rates of 190 patients treated by shock wave lithotripsy (SWL) for single, 5 to 10 mm, symptomatic and uncomplicated distal ureteric stones, treated with tamsulosin 0.4 mg, silodosin 8 mg or silodosin 4 mg as MET. Beside the stone-free rate after 4 weeks of treatment, we also investigated the pain intensity using the visual analogue scale (VAS), adverse events induced by the medication, safety of drug administration and the reasons for possible early treatment discontinuation.

Results
Silodosin 8 mg and tamsulosin 0.4 mg have similar results in terms of stone-free rate. For silodosin 4 mg the stone-free rate was significantly lower than for the previous two drugs. In patients treated with silodosin 4 mg the VAS was significantly higher than in patients treated with silodosin 8 mg or tamsulosin 0.4 mg, for all the follow-up visits.

Conclusions
Alpha-blocker treatment after ESWL with silodosin 8 mg offers a similar stone-free rate compared with tamsulosin 0.4 mg, being well tolerated. A lower dose of silodosin (4 mg) has significantly poor results, irrespective of ureteric stone size, with more frequent renal colic and severe pain.

keywords:

Does silodosin offer better results than tamsulosin as medical expulsive treatment after shock wave lithotripsy for single distal ureteric stones?

Catalin Pricop 1 , Dragomir Nicolae Șerban 2 , Ionela Lacramioara Șerban 2 , Alin Adrian Cumpanas 3 , Dragoș Puia 1

extracorporeal shock wave lithotripsy, expulsion rate, α-blockers

Catalin Pricop

¹

,

Dragomir Nicolae Șerban

²

,

Ionela Lacramioara Șerban

²

,

Alin Adrian Cumpanas

³

,

Dragoș Puia

¹