Drugs as a cause of perforating dermatoses – a literature review

Lidia Mądrzak; Izabela Staniszewska; Arkadiusz Moskwa; Agnieszka Kalińska-Bienias

doi:10.5114/dr.2024.144652

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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3/2024
vol. 111

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abstract:

Review article

Drugs as a cause of perforating dermatoses – a literature review

Lidia Mądrzak

¹

,

Izabela Staniszewska

¹

,

Arkadiusz Moskwa

¹

,

Agnieszka Kalińska-Bienias

¹

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland

Dermatol Rev/Przegl Dermatol 2024, 111, 209-221

DOI: https://doi.org/10.5114/dr.2024.144652

Online publish date: 2024/11/08

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Perforating dermatoses represents a diverse group of skin diseases characterised by extrusion of dermal materials through the skin. Perforating dermatoses are grouped according to the types of eliminated material and clinical features into the following: reactive perforating collagenosis, elastosis perforans serpiginous, perforating folliculitis, and Kyrle’s disease. We conducted a literature review to investigate the associations between perforating dermatoses and drugs. Perforating dermatoses can be induced by the molecularly targeted therapy drugs (sorafenib, nilotinib, dasatinib, erlotinib, gefitinib, vemurafenib, lenvatinib, sirolimus, bevacizumab, necitumumab, panitumumab, cetuximab, bendamustine-rituximab, terepril), monoclonal antibodies (infliximab, etanercept, ranibizumab, natalizumab), as well as immunomodulatory imide drugs (lenalidomide, leflunomide), antiretroviral drugs (indinavir, telaprevir) and penicillamine. Sorafenib is the most common molecularly targeted therapy drug which was described as a cause of perforating dermatoses. The mechanisms responsible for inducing perforating dermatoses with drugs are unknown.

keywords:

Drugs as a cause of perforating dermatoses – a literature review

Lidia Mądrzak 1 , Izabela Staniszewska 1 , Arkadiusz Moskwa 1 , Agnieszka Kalińska-Bienias 1

perforating dermatoses, molecularly targeted therapy, kinase inhibitors, monoclonal antibodies, acquired perforating dermatoses

Lidia Mądrzak

¹

,

Izabela Staniszewska

¹

,

Arkadiusz Moskwa

¹

,

Agnieszka Kalińska-Bienias

¹