Duże ropnie na granicy segmentu VII i VIII wątroby leczone skutecznie farmakologicznie – empirycznie dobraną antybiotykoterapią – u choregona cukrzycę

Introduction

Liver abscesses are focal necroinflammatory lesions of bacterial (pyogenic liver abscess – PLA), amoebic (amoebic liver abscess – ALA), or fungal origin. They occur from biliary disease, as a result of the portal system, via the hepatic artery and adjacent organs. The most frequent aetiologic agents are anaerobic bacteria such as Klebsiella, Streptococcus, Pseudomonas, and Escherichia [1–10]. Clinical symptoms are unspecific. They include high fever and right upper quadrant abdominal pain. They may also be nausea, vomiting and jaundice. In laboratory tests the following are noted: leucocytosis, anaemia, elevated liver enzymes, and elevated C-reactive protein reaction (CRP) levels. Blood cultures are positive in 50% of cases [5]. The diagnosis is based on laboratory tests and imaging studies – abdominal ultrasound and/or computed tompography (CT) scans. Liver abscesses are usually situated in the right liver with diameters of 1.4–9.5 cm (average: 4.5 am), round in shape, and well separated from the liver tissue. Treatment depends on the clinical condition of the patient, and the size and location of the abscesses. In most of patients combination therapy is used – antibiotics and percutaneous treatment (aspiration or drainage). This method of treatment is currently the recommended procedure because of its effectiveness and safety – it is a minimally invasive procedure and does not require general anaesthesia. According to some authors percutaneous drainage is essential in the treatment of liver abscesses [3]. The most common causes of this treatment failure are multiple abscesses, abscesses of large size with thick wall and technical difficulties. In cases of failure of the percutaneous drainage the treatment is based on surgery and antibiotic treatment. However, surgery should not be considered only as a second-line treatment. The urgent laparotomy is the standard therapy in a case when appear abscess rupture into the peritoneal cavity and concomitant pathologies. Some authors agree that surgery must be implemented as a first-line treatment in patients with a high risk of death in order to increase their chances of survival [2]. The mortality rate of untreated pyogenic liver abscess is nearly 100%.

Case report

A 62-year-old man with type 2 diabetes treated with oral medications, hypertension and psoriasis was admitted to the Department because of fever lasting from 2 weeks with concomitant loss of body weight (5 kg) and high glucose levels in the blood. On admission the patient was cardiopulmonarily and respiratorily stable. On physical examination no abnormalities were found. In laboratory tests increased concentrations of CRP (242.3 mg/l) with slightly higher leucocytosis (WBC 11.1 k/ml) were observed. Blood and urine cultures were without any signs of bacterial growth. The concentration of pro-calcitonin was 0.24 ng/ml. The patient had abdominal ultrasound, which revealed two focal lesions in the right lobe of the liver, located next to each other with reduced echogenicity. In addition, the liver was not enlarged and had normal echogenicity. The abdominal CT with contrast was performed, which showed two focal lesions with the appearance of abscesses on the border of liver segments VII and VIII, measuring 44 × 55 mm and 67 × 68 mm. There were no other abnormalities on the CT scans. Visceral and retroperitoneal lymph nodes were not enlarged. In echocardiography there was no infective endocarditis features or abscesses in the muscle of the left ventricle. Since the beginning of hospitalisation the patient received empirical broad-spectrum antibiotics (cefuroxime) to which were added in the following days gentamicin and metronidazole. During the treatment the patient had no high fever. After the reduction in CRP (23 mg/l), normalisation of leukocyte count, and good glycaemic control, the patient was discharged home with the recommendation to continue therapy with metronidazole, ceftibuten, and fluconazole. After about 4 weeks, still during the antibiotic treatment, the patient was again admitted to the Department to assess the effectiveness of treatment. In laboratory studies there were no significant abnormalities beyond slightly elevated levels of CRP (6.6 mg/l in norm to 5 mg/l). Computer tomography confirmed the reduction in the dimensions of liver abscesses to 47 × 35 mm and a diameter of 23 mm. Abscesses had a thick wall and a small amount of fluid in the central portion. The patient was consulted by a surgeon and was not qualified to surgery. Percutaneous drainage was left to consider, from which the patient was disqualified by a radiologist. In view of the substantial thickness of the walls of abscesses, the use of multiple antibiotics, broad spectrum, normal markers of inflammation, and after further bacteriological consultation it was decided not to continue antibiotic treatment. Eight months after identification of the liver abscesses the patient was readmitted to the Department.
In the controls, abdominal computed tomography was performed at the location of the previously identified abscesses, revealing hypodense of liver tissue – lesions of diameter of approx. 19 mm and 15 mm corresponding to scarring of the liver. The CT pictures present changes in stages before treatment (Figure 1), during treatment (Figure 2), after treatment (Figure 3) (each CT shows the arterial and venous phase).

Discussion

Percutaneous drainage under ultrasound guidance is essential in the treatment of pyogenic liver abscesses. Many authors believe that it is not possible to cure permanently patients with liver abscesses only by pharmacological treatment [3]. It is especially difficult for patients with diabetes [11] taking into account the negative blood cultures collected several times [12]. Empiric broad-spectrum antibiotics are recommended initially until culture results are available. No randomised controlled studies have evaluated the optimal duration of antibiotic therapy for pyogenic liver abscess. Typical duration of antibiotic therapy is at least 4 to 6 weeks [5, 9]. The effectiveness of such treatment is uncertain and requires the control of inflammatory marker tests, imaging studies (in the case described above the abdominal CT were performed thrice). Importantly, radiologic abnormalities resolve more slowly than clinical and biochemical features. Abscesses smaller than 10 cm can take up to 16 weeks to resolve. In this case it is extremely important to work with a microbiologist, and to have the possibility of surgical consultation [13]. Infectious disease, gastroenterology, interventional radiology, and general surgical consultations are recommended for any patient with hepatic abscess [5]. Empirically chosen antibiotic therapy was carried out including frequent measurements of the risk index IR, enabling effective use of the therapy [14].

Conflict of interest

The authors declare no conflict of interest.

References

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Address for correspondence:

Beata P. Kraśnicka-Sokół MD, PhD
3rd Department of Internal Medicine,
Subdivision of Toxicology, AZA Treatment Subdivision, Subdivision of Nephrology
Praski Hospital of the Transfiguration of Jesus
al. Solidarności 67, 03-401 Warsaw, Poland
Phone: +48 606 613 901
E-mail: beakrassokol@op.pl