eISSN: 2391-6052
ISSN: 2353-3854
Alergologia Polska - Polish Journal of Allergology
Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Suplementy Zeszyty specjalne Rada naukowa Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac Opłaty publikacyjne Standardy etyczne i procedury
Panel Redakcyjny
Zgłaszanie i recenzowanie prac online
4/2023
vol. 10
 
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Opis przypadku

Dwa typy reakcji nadwrażliwości: anafilaksja oraz symetryczna, wyprzeniowa i zgięciowa osutka wywołana lekiem (SDRIFE), które wystąpiły u pacjenta po zażyciu aminopenicyliny

Lesia Rozłucka
1
,
Radosław Gawlik
1
,
Joanna Glück
1

  1. Department of Internal Medicine, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland
Alergologia Polska – Polish Journal of Allergology 2023; 10, 4: 315–318
Data publikacji online: 2023/12/15
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Metryki PlumX:


We present a rare case of a patient who experienced both immediate and delayed types of drug hypersensitivity reaction (DHR) to aminopenicillin with good tolerance of another β-lactam. A 56-year-old female patient reported allergic reactions to several antibiotics. After the co-administration of nonsteroidal anti-inflammatory drugs (NSAIDs) and amoxicillin/clavulanic acid the patient presented with anaphylactic shock. At the same time, the patient reported good amoxicillin tolerance. During hospitalization, DHR to NSAIDs was excluded by oral provocation. Due to the unclear history of β-lactam allergy, after negative skin test results, an oral provocation test with amoxicillin was performed. Four hours after the administration of the last dose, the patient developed symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) with temperature increase to 38.5°C. Laboratory tests showed increased inflammatory parameters. After treatment with dexamethasone, paracetamol and bilastine, a gradual regression of skin rash and normalization of inflammatory parameters were observed. Further work-up confirmed good tolerance of cefuroxime axetil.


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