EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS

Mykola Shved; Olena Prokopovych; Sofiya Lypovetska; Svitlana Heryak; Yaroslav Kitsak

doi:10.5114/hpc.2017.71891

eISSN: 2354-0265
ISSN: 2353-6942

Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO

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abstract:

Original paper

EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS

Mykola Shved

¹

,

Olena Prokopovych

¹

,

Sofiya Lypovetska

¹

,

Svitlana Heryak

¹

,

Yaroslav Kitsak

¹

I. Horbachevsky Ternopil State Medical University; Ministry of Public Health, Ukraine

Health Prob Civil. 2017; 11(4): 293-299

DOI: https://doi.org/10.5114/hpc.2017.71891

Online publish date: 2018/01/24

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AMA

Shved M, Prokopovych O, Lypovetska S, Heryak S, Kitsak Y. EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS. Health Problems of Civilization. 2017;11(4):293-299. doi:10.5114/hpc.2017.71891.

APA

Shved, M., Prokopovych, O., Lypovetska, S., Heryak, S.,  & Kitsak, Y. (2017). EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS. Health Problems of Civilization, 11(4), 293-299. https://doi.org/10.5114/hpc.2017.71891

Chicago

Shved, Mykola, Olena Prokopovych, Sofiya Lypovetska, Svitlana Heryak,  and Yaroslav Kitsak. 2017. "EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS". Health Problems of Civilization 11 (4): 293-299. doi:10.5114/hpc.2017.71891.

Harvard

Shved, M., Prokopovych, O., Lypovetska, S., Heryak, S.,  and Kitsak, Y. (2017). EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS. Health Problems of Civilization, 11(4), pp.293-299. https://doi.org/10.5114/hpc.2017.71891

MLA

Shved, Mykola et al. "EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS." Health Problems of Civilization, vol. 11, no. 4, 2017, pp. 293-299. doi:10.5114/hpc.2017.71891.

Vancouver

Shved M, Prokopovych O, Lypovetska S, Heryak S, Kitsak Y. EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS. Health Problems of Civilization. 2017;11(4):293-299. doi:10.5114/hpc.2017.71891.

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Background. The study has shown that functional liver disorders develop in patients with MI, which requires correction.

Material and methods. The study involved 149 patients with acute MI. All examinations were repeated several times on the 1, 14 and 28 day of the treatment.

Results. The patients with functional liver disorders have a higher incidence of epistenocardial pericarditis, arrhythmia and systolic dysfunction. They are characterised by highly activated lipid peroxidation and immunological disorders. A combined therapy with quercetin resulted in improving hemodynamics and reducing the manifestations of liver dysfunction. RNA-containing drug significantly improved the immune status and reduced signs of immuno-inflammatory syndromes.

Conclusions. 1.In patients with MI and functional liver disorders, the primary pathological process is characterised by significant violations of systolic and diastolic function of the heart, more frequent development of complications, activation of lipid peroxidation and secondary immunodeficiency. 2. The inclusion of bioflavonoid quercetin in the treatment of patients with MI helps to restore the antioxidant defence system, improve myocardial contractile function and reduce clinical laboratory manifestations of cytolytic and cholestatic syndromes in patients due to antioxidant and membrane stabilizing properties of the drug. 3. The usage of the RNA-containing drug Nuclex improves immune reactivity, reduces symptoms of expressed mesenchymal-inflammatory and necro-resorptive syndromes in patients with MI and functional liver disorders.

keywords:

EFFICIENCY OF BIOFLAVONOID QUERCETIN AND RNA-CONTAINING DRUG SODIUM NUCLEINAT IN COMPLEX TREATMENT OF PATIENTS WITH MYOCARDIAL INFARCTION AND FUNCTIONAL LIVER DISORDERS

Mykola Shved 1 , Olena Prokopovych 1 , Sofiya Lypovetska 1 , Svitlana Heryak 1 , Yaroslav Kitsak 1

myocardial infarction, liver function, lipid peroxidation, quercetin, sodium nucleinat

Mykola Shved

¹

,

Olena Prokopovych

¹

,

Sofiya Lypovetska

¹

,

Svitlana Heryak

¹

,

Yaroslav Kitsak

¹