EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCH<br>From mutation to methylation – molecular markers in lung cancer

Marzena Anna Lewandowska; Katarzyna Grębicka; Agnieszka Chrustek; Ilona Kujawska; Aleksandra Zaleska; Janusz Kowalewski

doi:10.5114/kitp.2013.36136

eISSN: 1897-4252
ISSN: 1731-5530

Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery

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abstract:

EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCH
From mutation to methylation – molecular markers in lung cancer

Marzena Anna Lewandowska

,

Katarzyna Grębicka

,

Agnieszka Chrustek

,

Ilona Kujawska

,

Aleksandra Zaleska

,

Janusz Kowalewski

Kardiochirurgia i Torakochirurgia Polska 2013; 10 (2): 148–153

DOI: https://doi.org/10.5114/kitp.2013.36136

Online publish date: 2013/07/09

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AMA

Lewandowska M, Grębicka K, Chrustek A, Kujawska I, Zaleska A, Kowalewski J. EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCHFrom mutation to methylation – molecular markers in lung cancer. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2013;10(2):148-153. doi:10.5114/kitp.2013.36136.

APA

Lewandowska, M., Grębicka, K., Chrustek, A., Kujawska, I., Zaleska, A.,  & Kowalewski, J. (2013). EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCHFrom mutation to methylation – molecular markers in lung cancer. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 10(2), 148-153. https://doi.org/10.5114/kitp.2013.36136

Chicago

Lewandowska, Marzena Anna, Katarzyna Grębicka, Agnieszka Chrustek, Ilona Kujawska, Aleksandra Zaleska,  and Janusz Kowalewski. 2013. "EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCHFrom mutation to methylation – molecular markers in lung cancer". Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery 10 (2): 148-153. doi:10.5114/kitp.2013.36136.

Harvard

Lewandowska, M., Grębicka, K., Chrustek, A., Kujawska, I., Zaleska, A.,  and Kowalewski, J. (2013). EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCHFrom mutation to methylation – molecular markers in lung cancer. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 10(2), pp.148-153. https://doi.org/10.5114/kitp.2013.36136

MLA

Lewandowska, Marzena Anna et al. "EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCHFrom mutation to methylation – molecular markers in lung cancer." Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, vol. 10, no. 2, 2013, pp. 148-153. doi:10.5114/kitp.2013.36136.

Vancouver

Lewandowska M, Grębicka K, Chrustek A, Kujawska I, Zaleska A, Kowalewski J. EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCHFrom mutation to methylation – molecular markers in lung cancer. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2013;10(2):148-153. doi:10.5114/kitp.2013.36136.

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Lung cancer is one of the most common types of malignant neoplasms in Poland and in the world, and is associated with the worst prognosis. Within recent years, significant progress has been made when it comes to high-throughput and high-resolution technologies in the field of molecular biology, i.e. next-generation sequencing, microarrays, and mass spectrometry, which contributed to the development of research in the fields of genomics, transcriptomics and epigenetics in lung cancer. Implementing the results achieved by these disciplines quickly allows for the analysis of somatic point mutations or translocations to be used in molecular cancer diagnostics, and, thus, for the personalization of treatment for patients with non-small cell lung cancer (NSCLC). Unfortunately, certain markers and prognostic predictors that could facilitate the detection of lung cancer in its early stages are yet to be found.

keywords:

EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCHFrom mutation to methylation – molecular markers in lung cancer

Marzena Anna Lewandowska , Katarzyna Grębicka , Agnieszka Chrustek , Ilona Kujawska , Aleksandra Zaleska , Janusz Kowalewski

molecular biomarkers, personalized oncology, molecular diagnostics

EXPERIMENTAL CARDIOVASCULAR AND LUNG RESEARCH
From mutation to methylation – molecular markers in lung cancer

Marzena Anna Lewandowska

,

Katarzyna Grębicka

,

Agnieszka Chrustek

,

Ilona Kujawska

,

Aleksandra Zaleska

,

Janusz Kowalewski