Early transformation event from follicular lymphoma: our experience of four cases

Anurag Mehta; Diksha Karki; Prathyusha Gudapati

doi:10.5114/pjp.2022.120026

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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2/2022
vol. 73

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abstract:

Case report

Early transformation event from follicular lymphoma: our experience of four cases

Anurag Mehta

¹

,

Diksha Karki

¹

,

Prathyusha Gudapati

¹

Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India

Pol J Pathol 2022; 73 (2): 166-175

DOI: https://doi.org/10.5114/pjp.2022.120026

Online publish date: 2022/10/04

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Follicular lymphoma (FL) is a mature B-cell lymphoma that can transform into a more aggressive disease such as diffuse large B-cell lymphoma, Burkitt lymphoma, or precursor B-lymphoblastic leukaemia/lymphoma. The process of transformation of FL occurs by the acquisition of additional genetic alterations, e.g. c-MYC rearrangement, TP53, and cyclin D1 inactivation. Herein, we describe four such cases of FL that transformed into more aggressive B-cell non-Hodgkin lymphomas within six months of their initial diagnosis. Subsequent testing of c-myc, P53 and cyclin D1 by immunohistochemistry and fluorescence in situ hybridization was done to further analyse their role in the process of transformation.

keywords:

Early transformation event from follicular lymphoma: our experience of four cases

Anurag Mehta 1 , Diksha Karki 1 , Prathyusha Gudapati 1

diffuse large B-cell lymphoma, follicular lymphoma, precursor B-lymphoblastic lymphoma, transformation

Anurag Mehta

¹

,

Diksha Karki

¹

,

Prathyusha Gudapati

¹