eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
1/2023
vol. 18
 
Share:
Send email
Share:
abstract:
Original paper

Effect of acute kidney injury on hospital-based outcomes in patients admitted for variceal hemorrhage. Analysis of national inpatient sample database

Zahid Ijaz Tarar
1
,
Muhammad Usman Zafar
2
,
Umer Farooq
3
,
Faisal Kamal
4
,
Faisal Inayat
5
,
Yasir Rajwana
6
,
Ghulam Ghous
1
,
Harleen Kaur Chela
7
,
Veysel Tahan
7
,
Ebubekir Daglilar
7

  1. Department of Medicine, University of Missouri, Columbia, MO, United States
  2. Lehigh Valley Health Network, Allentown, PA, United States
  3. Loyola Medicine/ MacNeal Hospital, Berwyn IL, United States
  4. Department of Gastroenterology, University of California, San Francisco, United States
  5. Department of Medicine, Allam Iqbal Medical College, Pakistan
  6. Department of Internal Medicine, Jersey City Medical Center, United States
  7. Department of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, United States
Gastroenterology Rev 2023; 18 (1): 85–92
DOI: https://doi.org/10.5114/pg.2022.115135
Online publish date: 2022/03/31
View full text Get citation
 
PlumX metrics:
Introduction
Acute kidney injury (AKI) is known to be a marker of mortality in patients with cirrhosis and variceal hemorrhage.

Aim
To study the effect of AKI on hospital-based outcomes in patients with variceal hemorrhage.

Material and methods
We obtained data from the National Inpatient Sample for the years 2016–2018. Study inclusion criteria comprised adult variceal hemorrhage patients who also had AKI. The primary outcome of interest was in-hospital mortality. Secondary outcomes were length of stay, hospital charge, shock, blood transfusion, and ICU admission. We also determined the independent predictors of mortality in variceal hemorrhage patients using multivariate regression analysis. We used 2 different methods: multivariate logistic regression and propensity matching to adjust for confounders.

Results
The number of people included in this study was 124,430, of whom 32,315 (26%) had AKI. Mortality in variceal hemorrhage patients with AKI was 30.4% in comparison to 4.8% without AKI. The presence of AKI was associated with increased odds of mortality (AOR = 8.28, 95% CI: 7.45–9.20, p < 0.01), ICU admissions (AOR = 4.76, 95% CI: 4.42–5.13, p < 0.01), blood transfusion (AOR = 1.24, 95% CI: 1.15–1.32, p < 0.01), and shock (AOR = 3.41, 95% CI 3.07–3.79, p < 0.01). The patients with AKI also had increased length of stay and hospital charges. Higher Charlson co-morbidity index, African American race, and being admitted to large sized hospital were independently associated with increased mortality.

Conclusions
After analyzing the combined NIS dataset of 2016–2018, we concluded that patients admitted with variceal hemorrhage who has AKI are prone to adverse hospital outcomes.

keywords:

mortality, cirrhosis, acute kidney injury, variceal hemorrhage, nationwide study
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.