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Videosurgery and Other Miniinvasive Techniques
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3/2023
vol. 18
 
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Anaesthesiology
abstract:
Original paper

Effect of dexmedetomidine on perioperative haemodynamics and early cognitive function in elderly patients undergoing laparoscopic surgery

Qiong Li
1
,
Li-ying Fu
1
,
Yue-hong Zhao
2
,
Wei-gang Shi
3
,
Wen Sun
1
,
Xiao-nan Zhang
1
,
Lin-shu Cheng
1
,
Xi-qian Ma
1

  1. Department of Anaesthesiology, Shijiazhuang Sixth Hospital, Shijiazhuang, Hebei, China
  2. Department of Obstetrics, Ningjin County Maternal and Child Health Hospital, Xingtai, Hebei, China
  3. Department of Anaesthesiology, Handan First Hospital, Handan, Hebei, China
Videosurgery Miniinv 2023; 18 (3): 533–540
DOI: https://doi.org/10.5114/wiitm.2023.130329
Online publish date: 2023/08/04
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Introduction
Laparoscopic minimally invasive surgery has been widely used in the diagnosis and treatment of gynaecological diseases.

Aim
To investigate the effect of dexmedetomidine on perioperative haemodynamics and cognitive function in elderly gynaecological patients who underwent laparoscopic surgery.

Material and methods
Clinical baseline characteristics, haemodynamic parameters, renin activity, norepinephrine level, cognitive function, pain level, and sedation were compared between the 2 groups.

Results
At T4 (10 min after extubation) and T5 (1 h after extubation), significant differences were found in systolic blood pressure, diastolic blood pressure, and heart rate between the 2 groups (p < 0.05); renin activity and norepinephrine level were much lower in the dexmedetomidine group than in the control group at T3 (10 min before extubation) and T4 (p < 0.05). One day before surgery, there were no significant differences in Mini-mental state examination (MMSE), visual analogue scale (VAS), and Ramsay scores between the 2 groups (p > 0.05), but the MMSE score 1 day after surgery and the Ramsay score at 12 h after surgery in the dexmedetomidine group were much higher than that in the control group (p < 0.05). Notably, at 2, 4, 12, 24, and 48 h after surgery, the VAS score in the dexmedetomidine group was significantly lower than that in the control group (p < 0.05).

Conclusions
Dexmedetomidine has a better clinical effect in improving perioperative haemodynamics and early cognitive function in elderly gynaecological patients who received laparoscopic surgery.

keywords:

dexmedetomidine, elderly gynaecology, laparoscopic surgery, perioperative, haemodynamic, cognitive function
  
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