Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts

Sylwia Klewin-Steinböck; Agnieszka Nowak-Terpiłowska; Zygmunt Adamski; Katarzyna Grocholewicz; Marzena Wyganowska-Świątkowska

doi:10.5114/ada.2020.94256

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts

Sylwia Klewin-Steinböck

¹

,

Agnieszka Nowak-Terpiłowska

²

,

Zygmunt Adamski

³

,

Katarzyna Grocholewicz

⁴

,

Marzena Wyganowska-Świątkowska

¹

Department of Dental Surgery and Periodontology, Poznan University of Medical Sciences, Poznan, Poland
Department of Biochemistry and Biotechnology, Poznan University of Life Sciences, Poznan, Poland
Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
Department of Interdisciplinary Dentistry, Pomeranian Medical University, Szczecin, Poland

Adv Dermatol Allergol 2021; XXXVIII (3): 440–445

DOI: https://doi.org/10.5114/ada.2020.94256

Online publish date: 2020/04/07

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AMA

Klewin-Steinböck S, Nowak-Terpiłowska A, Adamski Z, Grocholewicz K, Wyganowska-Świątkowska M. Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(3):440-445. doi:10.5114/ada.2020.94256.

APA

Klewin-Steinböck, S., Nowak-Terpiłowska, A., Adamski, Z., Grocholewicz, K.,  & Wyganowska-Świątkowska, M. (2021). Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(3), 440-445. https://doi.org/10.5114/ada.2020.94256

Chicago

Klewin-Steinböck, Sylwia, Agnieszka Nowak-Terpiłowska, Zygmunt Adamski, Katarzyna Grocholewicz,  and Marzena Wyganowska-Świątkowska. 2021. "Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 38 (3): 440-445. doi:10.5114/ada.2020.94256.

Harvard

Klewin-Steinböck, S., Nowak-Terpiłowska, A., Adamski, Z., Grocholewicz, K.,  and Wyganowska-Świątkowska, M. (2021). Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(3), pp.440-445. https://doi.org/10.5114/ada.2020.94256

MLA

Klewin-Steinböck, Sylwia et al. "Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 38, no. 3, 2021, pp. 440-445. doi:10.5114/ada.2020.94256.

Vancouver

Klewin-Steinböck S, Nowak-Terpiłowska A, Adamski Z, Grocholewicz K, Wyganowska-Świątkowska M. Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(3):440-445. doi:10.5114/ada.2020.94256.

Collagen as a biomaterial is widely used for tissue regeneration due to various advantages including its biodegradation, biocompatibility, and low allergenicity. Along with aesthetic medicine development, collagen is also used in the injectable form as a tissue biostimulator. The area of our study was collagen’s impact on fibroblast activity and apoptosis. The research showed that atelocollagen decreases metabolic activity of fibroblasts, but also showed an increasing number of living cells after 48 h and 72 h incubation under the influence of collagen.

keywords:

Effect of injectable equine collagen type I on metabolic activity and apoptosis of gingival fibroblasts

Sylwia Klewin-Steinböck 1 , Agnieszka Nowak-Terpiłowska 2 , Zygmunt Adamski 3 , Katarzyna Grocholewicz 4 , Marzena Wyganowska-Świątkowska 1

gingival fibroblasts, equine collagen, cytotoxicity, apoptosis

Sylwia Klewin-Steinböck

¹

,

Agnieszka Nowak-Terpiłowska

²

,

Zygmunt Adamski

³

,

Katarzyna Grocholewicz

⁴

,

Marzena Wyganowska-Świątkowska

¹