Effect of ultra-endurance exercise on left ventricular performance and plasma cytokines in healthy trained men

K Krzemiński; M Buraczewska; Z Miśkiewicz; J Dąbrowski; M Steczkowska; A Kozacz; A Ziemba

doi:10.5604/20831862.1189767

eISSN: 2083-1862
ISSN: 0860-021X

Biology of Sport

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1/2016
vol. 33

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abstract:

Original paper

Effect of ultra-endurance exercise on left ventricular performance and plasma cytokines in healthy trained men

K Krzemiński

¹

,

M Buraczewska

¹

,

Z Miśkiewicz

¹

,

J Dąbrowski

¹

,

M Steczkowska

¹

,

A Kozacz

¹

,

A Ziemba

¹

Department of Applied Physiology, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland

Biol. Sport 2016;33:63-69

DOI: https://doi.org/10.5604/20831862.1189767

Online publish date: 2016/01/13

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The purpose of this study was to investigate the effect of ultra-endurance exercise on left ventricular (LV) performance and plasma concentration of interleukin (IL)-6, IL-10, IL-18 and tumour necrosis factoralpha (TNF-IX) as well as to examine the relationships between exercise-induced changes in plasma cytokines and those in echocardiographic indices of LV function in ultra-marathon runners. Nine healthy trained men (mean age 3011.0 years) participated in a 100-km ultra-marathon. Heart rate, blood pressure, ejection fraction (EF), fractional shortening (FS), ratio of early (E) to late (A) mitral inﬂow peak velocities (E/A), ratio of early (E') to late (A') diastolic mitral annulus peak velocities (E‘/A’) and E-wave deceleration time (DT) were obtained by echocardiography before, immediately after and in the 90th minute of the recovery period. Blood samples were taken before each echocardiographic evaluation. The ultra-endurance exercise caused significant increases in plasma IL-6, IL-10, IL-18 and TNF-α. Echocardiography revealed signiﬁcant decreases in both E and the E/A ratio immediately after exercise, without any significant changes in EF, FS, DT or the E/E’ ratio. At the 90th minute of the recovery period, plasma TNF-or and the E/A ratio did not differ significantly from the pre-exercise values, whereas FS was significantly lower than before and immediately after exercise. The increases in plasma TNF-or correlated with changes in FS (r=0.73) and DT (r=-0.73). It is concluded that ultra-endurance exercise causes alterations in LV diastolic function. The present data suggest that TNF-or might be involved in this effect.

keywords:

Effect of ultra-endurance exercise on left ventricular performance and plasma cytokines in healthy trained men

K Krzemiński 1 , M Buraczewska 1 , Z Miśkiewicz 1 , J Dąbrowski 1 , M Steczkowska 1 , A Kozacz 1 , A Ziemba 1

ultra-marathon, Doppler echocardiography, interleukins, tumour necrosis factor alpha

K Krzemiński

¹

,

M Buraczewska

¹

,

Z Miśkiewicz

¹

,

J Dąbrowski

¹

,

M Steczkowska

¹

,

A Kozacz

¹

,

A Ziemba

¹