Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata

Gokhan Cakirca; Vildan Manav; Hakim Celik; Gülben Saracoglu; Esra Nur Yetkin

doi:10.5114/ada.2019.83879

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata

Gokhan Cakirca

¹

,

Vildan Manav

²

,

Hakim Celik

³

,

Gülben Saracoglu

⁴

,

Esra Nur Yetkin

¹

Department of Biochemistry, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey
Department of Dermatology, Istanbul Training and Research Hospital, Istanbul, Turkey
Department of Physiology, Faculty of Medicine, Harran University, Sanlıurfa, Turkey
Department of Psychiatry, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey

Adv Dermatol Allergol 2020; XXXVII (3): 412-416

DOI: https://doi.org/10.5114/ada.2019.83879

Online publish date: 2019/03/26

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Introduction
Increased oxidative stress (OXS) and a high prevalence of psychiatric disorders are seen in alopecia areata (AA). However, OXS and psychiatric disorders have been studied separately in AA patients.

Aim
To determine the effects of anxiety and depression symptoms on OXS in AA patients.

Material and methods
The anxiety and depression levels of 33 AA patients and 33 normal controls (NC) were determined using the Hospital Anxiety and Depression Scale. The oxidative stress index (OSI) was calculated by measuring serum total antioxidant status (TAS) and total oxidant status (TOS) levels in AA patients and NC.

Results
The AA patients had higher anxiety and depression scores than NC (p < 0.001 for both). Total oxidant status (p = 0.002) and OSI (p < 0.001) values were higher, and TAS (p < 0.001) levels were lower, in patients with AA compared to NC. However, patients’ anxiety and depression scores were not correlated with the TAS, TOS, or OSI values (p > 0.05). There was no significant difference in TAS, TOS, or OSI values between patients with high and low anxiety or depression scores (p > 0.05).

Conclusions
These results show that OXS, anxiety, and depression scores were higher in patients with AA compared to NC. However, anxiety and depression scores were not associated with OXS in AA patients. More extensive studies should be performed to investigate the relationship between psychological status and OXS in patients with AA.

keywords:

Effects of anxiety and depression symptoms on oxidative stress in patients with alopecia areata

Gokhan Cakirca 1 , Vildan Manav 2 , Hakim Celik 3 , Gülben Saracoglu 4 , Esra Nur Yetkin 1

alopecia areata, oxidative stress, anxiety, depression

Gokhan Cakirca

¹

,

Vildan Manav

²

,

Hakim Celik

³

,

Gülben Saracoglu

⁴

,

Esra Nur Yetkin

¹