Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients

Bengu Cevirgen Cemil; Havva Hilal Ayvaz; Gulfer Ozturk; Can Ergin; Havva Kaya Akıs; Muzeyyen Gonul; Ercan Arzuhal

doi:10.5114/pdia.2016.56928

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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4/2016
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Original paper

Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients

Bengu Cevirgen Cemil

,

Havva Hilal Ayvaz

,

Gulfer Ozturk

,

Can Ergin

,

Havva Kaya Akıs

,

Muzeyyen Gonul

,

Ercan Arzuhal

Adv Dermatol Allergol 2016; XXXIII (4): 294–299

DOI: https://doi.org/10.5114/pdia.2016.56928

Online publish date: 2016/08/16

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AMA

Cemil B, Ayvaz H, Ozturk G, et al. Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(4):294-299. doi:10.5114/pdia.2016.56928.

APA

Cemil, B., Ayvaz, H., Ozturk, G., Ergin, C., Akıs, H.,  & Gonul, M. et al. (2016). Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(4), 294-299. https://doi.org/10.5114/pdia.2016.56928

Chicago

Cemil, Bengu Cevirgen, Havva Hilal Ayvaz, Gulfer Ozturk, Can Ergin, Havva Kaya Akıs, Muzeyyen Gonul,  and Ercan Arzuhal. 2016. "Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 33 (4): 294-299. doi:10.5114/pdia.2016.56928.

Harvard

Cemil, B., Ayvaz, H., Ozturk, G., Ergin, C., Akıs, H., Gonul, M.,  and Arzuhal, E. (2016). Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(4), pp.294-299. https://doi.org/10.5114/pdia.2016.56928

MLA

Cemil, Bengu Cevirgen et al. "Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 33, no. 4, 2016, pp. 294-299. doi:10.5114/pdia.2016.56928.

Vancouver

Cemil B, Ayvaz H, Ozturk G, Ergin C, Akıs H, Gonul M et al. Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(4):294-299. doi:10.5114/pdia.2016.56928.

Introduction: Isotretinoin has been successfully used for the treatment of acne vulgaris.

Aim: To investigate the effects of isotretinoin on body mass index (BMI), to determine whether isotretinoin causes any changes in serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients, and to correlate variables.

Material and methods: Thirty-two patients were included in this study. Oral isotretinoin was begun at a dose of 0.5–0.6 mg/kg and raised to 0.6–0.75 mg/kg. Pretreatment and posttreatment third-month BMI and adiponectin, leptin, and ghrelin serum levels were measured.

Results: The pre- and posttreatment BMI values were not significantly different. In addition, serum adiponectin and leptin levels were significantly increased following isotretinoin therapy while serum ghrelin levels were not different.

Conclusions: Isotretinoin may exert its anti-inflammatory activity by increasing leptin and adiponectin levels.

keywords:

Effects of isotretinoin on body mass index, serum adiponectin, leptin, and ghrelin levels in acne vulgaris patients

Bengu Cevirgen Cemil , Havva Hilal Ayvaz , Gulfer Ozturk , Can Ergin , Havva Kaya Akıs , Muzeyyen Gonul , Ercan Arzuhal

acne vulgaris, adipocytokines, body mass index, ghrelin, isotretinoin

Bengu Cevirgen Cemil

,

Havva Hilal Ayvaz

,

Gulfer Ozturk

,

Can Ergin

,

Havva Kaya Akıs

,

Muzeyyen Gonul

,

Ercan Arzuhal