eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
3/2013
vol. 38
 
Share:
Send email
Share:
abstract:

Effects of ultraviolet radiation on Langerhans cells

Dorota Chomiczewska-Skóra
,
Angelika Adamus
,
Ewa Trznadel-Grodzka
,
Helena Rotsztejn

(Centr Eur J Immunol 2013; 38 (393-398)
DOI: https://doi.org/10.5114/ceji.2013.37742
Online publish date: 2013/10/28
View full text Get citation
 
PlumX metrics:
Research on penetration of ultraviolet (UV) radiation into human skin shows that about 20% of UVA and 10% of UVB can reach the basal layer of the epidermis. As a consequence, Langerhans cells (LCs), located in suprabasal layers, are subject to the influence of the two types of UV radiation. This phenomenon leads to quantitative and qualitative alterations in LCs, including reduction in their number in the epidermis and modifications in morphology and immune functions. Studies show that two mechanisms may be responsible for their depletion from epidermis, namely, migration to the lymph nodes or induction of cell necrosis or apoptosis. UV radiation also affects the phenotype of LCs and their functions as antigen presenting cells. In recent years, the role of LCs in the UV-dependent immunosuppression and immune tolerance has been emphasized. The aim of the study is to review the literature about the influence of ultraviolet radiation on Langerhans cells.
keywords:

UVA, UVB, Langerhans cells, skin
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.