Biology of Sport
eISSN: 2083-1862
ISSN: 0860-021X
Biology of Sport
Current Issue Manuscripts accepted About the journal Editorial board Abstracting and indexing Archive Ethical standards and procedures Contact Instructions for authors Journal's Reviewers Special Information
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
Share:
Send email
Share:
Original paper

Effects of vitamin D3 supplementation on oxidative stress and antioxidant enzyme after strenuous endurance exercise in healthy young men: a double-blind, placebo-controlled trial

Cheng-Tse Yang
1
,
Pei-Wei Weng
2, 3
,
Li-Hui Chien
4
,
Sunil Kumar
5
,
Ming-Ta Yang
6, 7

  1. Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
  2. Department of Orthopaedics, School of Medicine, Taipei Medical University, Taipei, Taiwan
  3. International Ph.D. Program in Biomedical Engineering, Taipei Medical University, Taipei, Taiwan
  4. Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan, Taiwan
  5. Nottingham Law School (Patent), Nottingham Trent University, Nottingham, England
  6. Center for General Education, Taipei Medical University, Taipei, Taiwan
  7. Clinical Research Center, Taipei Medical University Hospital, Taipei, Taiwan
Biol Sport. 2025;42(1):137–144
DOI: https://doi.org/10.5114/biolsport.2025.139087
Online publish date: 2024/07/31
Article file
- 14_03622_Article.pdf  [0.86 MB]
Get citation
 
PlumX metrics:
 
1. Forman HJ, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov. 2021; 20(9):689–709.
2. Morry J, Ngamcherdtrakul W, Yantasee W. Oxidative stress in cancer and fibrosis: opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles. Redox Biol. 2017; 11:240–53.
3. Kowalczyk P, Sulejczak D, Kleczkowska P, Bukowska-Ośko I, Kucia M, Popiel M, et al. Mitochondrial oxidative stress— a causative factor and therapeutic target in many diseases. Int J Mol Sci. 2021; 22(24):13384.
4. Galli D, Carubbi C, Masselli E, Vaccarezza M, Presta V, Pozzi G, et al. Physical activity and redox balance in the elderly: signal transduction mechanisms. Appl Sci. 2021; 11(5):2228.
5. Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: friend or foe? J Sport Health Sci. 2020; 9(5):415–425.
6. Kawamura T, Muraoka I. Exercise-induced oxidative stress and the effects of antioxidant intake from a physiological viewpoint. Antioxidants. 2018; 7(9):119.
7. Simioni C, Zauli G, Martelli AM, Vitale M, Sacchetti G, Gonelli A, et al. Oxidative stress: Role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget. 2018; 9(24):17181–17198.
8. D’Angelo S. Polyphenols: potential beneficial effects of these phytochemicals in athletes. Curr Sport Med Rep. 2020; 19(7):260–265.
9. Gancitano G, Reiter RJ. The multiple functions of melatonin: applications in the military setting. Biomedicines. 2022; 11(1):5.
10. Morawin B, Turowski D, Naczk M, Siatkowski I, Zembron-Lacny A. The combination of α-lipoic acid intake with eccentric exercise modulates erythropoietin release. Biol Sport. 2014; 31(3):179–85.
11. Aji AS, Yerizel E, Desmawati, Lipoeto NI. The association between lifestyle and maternal vitamin D during pregnancy in West Sumatra, Indonesia. Asia Pac J Clin Nutr. 2018; 27(6):1286–1293.
12. Small AG, Harvey S, Kaur J, Putty T, Quach A, Munawara U, et al. Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens. Commun Biol. 2021; 4(1):401.
13. Calella P, Cerullo G, Di Dio M, Liguori F, Di Onofrio V, Gallè F, et al. Antioxidant, anti-inflammatory and immunomodulatory effects of spirulina in exercise and sport: a systematic review. Front Nutr. 2022; 9:1048258.
14. Liu M-C, Weng P-W, Chen S-C, Liu T-H, Huang H-W, Huang C-T, et al. Immunologic, anti-inflammatory, and anti-muscle damage profile of supplemented vitamin D3 in healthy adults on strenuous endurance exercise. Biology. 2023; 12(5):657.
15. Wiseman H. Vitamin D is a membrane antioxidant. Ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS Lett. 1993; 326:285–288.
16. Latham CM, Brightwell CR, Keeble AR, Munson BD, Thomas NT, Zagzoog AM, et al. Vitamin D promotes skeletal muscle regeneration and mitochondrial health. Front Physiol. 2021; 12:660498.
17. Bhat M, Ismail A. Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis. J Steroid Biochem Mol Biol. 2015; 152:171–179.
18. Dzik K, Skrobot W, Flis DJ, Karnia M, Libionka W, Kloc W, et al. Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain. Eur J Appl Physiol. 2018; 118(1):143–151.
19. Ke CY, Yang FL, Wu WT, Chung CH, Lee RP, Yang WT, et al. Vitamin D3 reduces tissue damage and oxidative stress caused by exhaustive exercise. Int J Med Sci. 2016; 13(2):147–153.
20. Kalvandi F, Azarbayjani MA, Azizbeigi R, Azizbeigi K. Elastic resistance training is more effective than vitamin D3 supplementation in reducing oxidative stress and strengthen antioxidant enzymes in healthy men. Eur J Clin Nut. 2022; 76(4):610–615.
21. Tower J, Pomatto LCD, Davies KJA. Sex differences in the response to oxidative and proteolytic stress. Redox Biol. 2020; 31:101488.
22. Muscogiuri G, Barrea L, Somma CD, Laudisio D, Salzano C, Pugliese G, et al. Sex differences of vitamin D status across BMI classes: An observational prospective cohort study. Nutrients. 2019; 11(12):3034.
23. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911–1930.
24. Ogan D, Pritchett K. Vitamin D and the athlete: risks, recommendations, and benefits. Nutrients. 2013; 5(6):1856–1868.
25. Jung HC, Seo M-W, Lee S, Kim SW, Song JK. Vitamin D3 supplementation reduces the symptoms of upper respiratory tract infection during winter training in vitamin D-insufficient taekwondo athletes: a randomized controlled trial. Int J Env Res Pub He. 2018; 15(9):2003.
26. Lee MC, Ho CS, Hsu YJ, Huang CC. Live and heat-killed probiotic Lactobacillus Paracasei PS23 accelerated the improvement and recovery of strength and damage biomarkers after exercise-induced muscle damage. Nutrients. 2022; 14(21):4563.
27. Alessio HM, Hagerman AE, Fulkerson BK, Ambrose J, Rice RE, Wiley RL. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med Sci Sports Exerc. 2000; 32(9):1576–1581.
28. Paschalis V, Nikolaidis MG, Fatouros IG, Giakas G, Koutedakis Y, Karatzaferi C, et al. Uniform and prolonged changes in blood oxidative stress after muscle-damaging exercise. In Vivo. 2007; 21(5):877–883.
29. Henning T, Weber D. Redox biomarkers in dietary interventions and nutritional observation studies – From new insights to old problems. Redox Biol. 2021; 41:101922.
30. Bongiovanni T, Genovesi F, Nemmer M, Carling C, Alberti G, Howatson G. Nutritional interventions for reducing the signs and symptoms of exercise-induced muscle damage and accelerate recovery in athletes: current knowledge, practical application and future perspectives. Eur J Appl Physiol. 2020; 120(9):1965–1996.
31. Huang CC, Lin TJ, Lu YF, Chen CC, Huang CY, Lin WT. Protective effects of L-arginine supplementation against exhaustive exercise-induced oxidative stress in young rat tissues. Chin J Physiol. 2009; 52(5):306–315.
32. Nobari H, Nejad HA, Kargarfard M, Mohseni S, Suzuki K, Carmelo Adsuar J, et al. The effect of acute intense exercise on activity of antioxidant enzymes in smokers and non-smokers. Biomolecules. 2021; 11(2):171.
33. Lin AM, Chen K, Chao P. Antioxidative effect of vitamin D3 on zinc-induced oxidative stress in CNS. Ann N Y Acad Sci. 2005; 1053(1):319–329.
34. Mokhtari Z, Hekmatdoost A, Nourian M. Antioxidant efficacy of vitamin D. J Parathyr Dis. 2016; 5(1):11–16.
35. Abdrabbo M, Birch CM, Brandt M, Cicigoi KA, Coffey SJ, Dolan CC, et al. Vitamin D and COVID-19: A review on the role of vitamin D in preventing and reducing the severity of COVID-19 infection. Protein Sci.. 2021; 30(11):2206–2220.
36. Hoseini R, Rahim HA, Ahmed JK. Concurrent alteration in inflammatory biomarker gene expression and oxidative stress: how aerobic training and vitamin D improve T2DM. BMC Complement Altern Med. 2022; 22(1):1–13.
37. Heaney RP, Armas LA, Shary JR, Bell NH, Binkley N, Hollis BW. 25-Hydroxylation of vitamin D3: Relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr. 2008; 87(6):1738–1742.
38. Todd J, Madigan S, Pourshahidi K, McSorley E, Laird E, Healy M, et al. Vitamin D status and supplementation practices in elite Irish athletes: an update from 2010/2011. Nutrients. 2016; 8(8):485.
39. Savolainen L, Timpmann S, Mooses M, Mäestu E, Medijainen L, Tõnutare L, et al. Vitamin D supplementation does not enhance resistance training-induced gains in muscle strength and lean body mass in vitamin D deficient young men. Eur J Appl Physiol. 2021; 121(7):2077–2090.
Copyright: Institute of Sport. This is an Open Access article distributed under the terms of the Creative Commons CC BY License (https://creativecommons.org/licenses/by/4.0/). This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
  
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.