Efficacy of radiofrequency ablation versus laparoscopic liver resection for hepatocellular carcinoma in China: 
a comprehensive meta-analysis

Zhijun Li; Qiong Yu; Xiaozheng Lu; Yahui Liu; Bai Ji

doi:10.5114/wiitm.2021.105377

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abstract:

Meta-analysis

Efficacy of radiofrequency ablation versus laparoscopic liver resection for hepatocellular carcinoma in China: a comprehensive meta-analysis

Zhijun Li

^{1, 2}

,

Qiong Yu

²

,

Xiaozheng Lu

¹

,

Yahui Liu

¹

,

Bai Ji

¹

Department of Hepatobiliary and Pancreatic Surgery, the First Hospital, Jilin University, Changchun, China
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China

Videosurgery Miniinv 2021; 16 (3): 455–471

DOI: https://doi.org/10.5114/wiitm.2021.105377

Online publish date: 2021/04/14

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Introduction
Hepatocellular carcinoma (HCC) has been the second leading cause of cancer-related death in China. Radiofrequency ablation is a relatively novel treatment that may improve the treatment of HCC. Aim: To evaluate and compare the efficacy and safety of radiofrequency ablation (RFA) versus laparoscopic liver resection (LLR) in the treatment of HCC.

Material and methods
We searched for relevant published studies in English (PubMed, Cochrane Library, EMBASE) and in Chinese (CBM, CNKI and Wanfang) from their inception until September 23, 2019. The quality of included studies was evaluated by the Newcastle-Ottawa Scale.

Results
A total of 19 retrospective studies including 2038 patients were eligible for the meta-analysis. The results of the meta-analysis demonstrated that LLR was superior to RFA in terms of 3-year overall survival rate (OR = 0.62), 1 to 3-year disease-free survival rates (OR = 0.57; OR = 0.41, respectively) and local recurrence rates (OR = 2.71).

Conclusions
The meta-analysis demonstrates that laparoscopic liver resection should be preferred in tumors of size 3–5 cm, while for < 3 cm the long term results are equal.

keywords:

Efficacy of radiofrequency ablation versus laparoscopic liver resection for hepatocellular carcinoma in China: a comprehensive meta-analysis

Zhijun Li 1, 2 , Qiong Yu 2 , Xiaozheng Lu 1 , Yahui Liu 1 , Bai Ji 1

radiofrequency ablation, laparoscopic liver resection, small hepatocellular carcinoma, survival

Zhijun Li

^{1, 2}

,

Qiong Yu

²

,

Xiaozheng Lu

¹

,

Yahui Liu

¹

,

Bai Ji

¹