Endocan expression correlated with total volume 
of coronary artery dilation in patients with coronary artery ectasia

Sylwia Iwańczyk; Aleksander Araszkiewicz; Michał Borger; Mikołaj Kamiński; Michał Wrotyński; Ewa Chmara; Artur Cieślewicz; Artur Radziemski; Maciej Lesiak

doi:10.5114/aic.2020.99264

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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abstract:

Original paper

Endocan expression correlated with total volume of coronary artery dilation in patients with coronary artery ectasia

Sylwia Iwańczyk

¹

,

Aleksander Araszkiewicz

¹

,

Michał Borger

¹

,

Mikołaj Kamiński

¹

,

Michał Wrotyński

¹

,

Ewa Chmara

¹

,

Artur Cieślewicz

¹

,

Artur Radziemski

¹

,

Maciej Lesiak

¹

1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland

Adv Interv Cardiol 2020; 16, 3 (61): 294–299

DOI: https://doi.org/10.5114/aic.2020.99264

Online publish date: 2020/10/02

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AMA

Iwańczyk S, Araszkiewicz A, Borger M, et al. Endocan expression correlated with total volume 
of coronary artery dilation in patients with coronary artery ectasia. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2020;16(3):294-299. doi:10.5114/aic.2020.99264.

APA

Iwańczyk, S., Araszkiewicz, A., Borger, M., Kamiński, M., Wrotyński, M.,  & Chmara, E. et al. (2020). Endocan expression correlated with total volume 
of coronary artery dilation in patients with coronary artery ectasia. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 16(3), 294-299. https://doi.org/10.5114/aic.2020.99264

Chicago

Iwańczyk, Sylwia, Aleksander Araszkiewicz, Michał Borger, Mikołaj Kamiński, Michał Wrotyński, Ewa Chmara,  and Artur Cieślewicz et al. 2020. "Endocan expression correlated with total volume 
of coronary artery dilation in patients with coronary artery ectasia". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 16 (3): 294-299. doi:10.5114/aic.2020.99264.

Harvard

Iwańczyk, S., Araszkiewicz, A., Borger, M., Kamiński, M., Wrotyński, M., Chmara, E., Cieślewicz, A., Radziemski, A.,  and Lesiak, M. (2020). Endocan expression correlated with total volume 
of coronary artery dilation in patients with coronary artery ectasia. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 16(3), pp.294-299. https://doi.org/10.5114/aic.2020.99264

MLA

Iwańczyk, Sylwia et al. "Endocan expression correlated with total volume 
of coronary artery dilation in patients with coronary artery ectasia." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 16, no. 3, 2020, pp. 294-299. doi:10.5114/aic.2020.99264.

Vancouver

Iwańczyk S, Araszkiewicz A, Borger M, Kamiński M, Wrotyński M, Chmara E et al. Endocan expression correlated with total volume 
of coronary artery dilation in patients with coronary artery ectasia. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2020;16(3):294-299. doi:10.5114/aic.2020.99264.

Introduction
Inflammation and angiogenesis disturbances are considered as factors contributing to the development of coronary artery ectasias (CAE). Endocan (endothelial cell-specific molecule-1 – ESM-1) regulates both inflammatory and angiogenetic processes. However, there are no data about the correlation between endocan level and the severity of CAE measured with total volume of coronary artery dilation.

Aim
To assess whether the severity of the inflammatory process measured as endocan concentration correlates with the total volume of CAE.

Material and methods
We selected prospectively a total of 43 consecutive patients with coronary artery ectasia from 2240 patients who underwent coronary angiography in our center. Determination of endocan was performed by using the Human Endothelial cell-specific Molecule 1 (ECSM1/ENDOCAN) ELISA Kit. 3D QCA (three-dimensional quantitative coronary angiography) was used for coronary lesion and aneurysm quantification. The total volume of dilation was defined as the volume of all aneurysms and ectasias of coronary arteries in 1 patient.

Results
The mean volume of all aneurysms in 1 patient was 677 ±878.7 mm3. The total aneurysm volume was positively strongly correlated with endocan concentration (Pearson correlation coefficient: 0.811; 2-tailed p < 0.001).

Conclusions
Endocan is a potential marker of vascular wall damage mainly as a result of inflammation in the course of atherosclerosis, but also vascular remodeling as a result of a disturbance of pro- and anti-angiogenic processes. Endocan level reflects the intensity of the above processes and therefore correlates with the severity of CAE, measured as the total volume of dilation.

keywords:

Endocan expression correlated with total volume of coronary artery dilation in patients with coronary artery ectasia

Sylwia Iwańczyk 1 , Aleksander Araszkiewicz 1 , Michał Borger 1 , Mikołaj Kamiński 1 , Michał Wrotyński 1 , Ewa Chmara 1 , Artur Cieślewicz 1 , Artur Radziemski 1 , Maciej Lesiak 1

inflammation, coronary atherosclerosis, coronary aneurysms, angiogenic proteins

Sylwia Iwańczyk

¹

,

Aleksander Araszkiewicz

¹

,

Michał Borger

¹

,

Mikołaj Kamiński

¹

,

Michał Wrotyński

¹

,

Ewa Chmara

¹

,

Artur Cieślewicz

¹

,

Artur Radziemski

¹

,

Maciej Lesiak

¹