Endocrine aspects of breast tissue pathology

Włodzimierz Baranowski; Jacek Doniec

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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1/2005
vol. 4

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abstract:

Endocrine aspects of breast tissue pathology

Włodzimierz Baranowski

,

Jacek Doniec

Prz Menopauz 2005; 1: 10–14

Online publish date: 2005/02/15

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Physiology and pathology of breast tissues are reviewed in term of hormonal regulation. The breast tissue enzymes activity and its regulation mechanism(s) – so called ”the intracrine concept” – are discussed. Additionally, the state of the art of the receptor mechanisms as well as epigenetic action of estrogen metabolites like catecholestrogens and its metabolites (2-hydroxy-, 4-hydroxy-, 16α-hydroxy-derivatives) with potential carcinogenic action is described. Data on perspectives of specific estrogen metabolites for clinical application and for epidemiological (screening) tests are also presented.

keywords:

Endocrine aspects of breast tissue pathology

Włodzimierz Baranowski , Jacek Doniec

breast, estrogens, progestagens, cancer

Włodzimierz Baranowski

,

Jacek Doniec