eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
6/2022
vol. 39
 
Share:
Send email
Share:
abstract:
Original paper

Epidermal barrier function in patients after allogeneic hematopoietic stem cell transplantation – a pilot study

Adriana Polańska
1
,
Anna Łojko-Dankowska
2
,
Anna Czyż
3
,
Zygmunt Adamski
1
,
Ryszard Żaba
1
,
Lidia Gil
2
,
Aleksandra Dańczak-Pazdrowska
1

  1. Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
  2. Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, Poland
  3. Department of Hematology, Blood Cancer and Bone Marrow Transplantation, Medical University of Wroclaw, Wroclaw, Poland
Adv Dermatol Allergol 2022; XXXIX (6): 1083-1087
DOI: https://doi.org/10.5114/ada.2022.116778
Online publish date: 2022/06/07
View full text Get citation
 
Introduction
The skin is the typically and predominantly affected organ in patients after allogeneic hematopoietic stem cell transplantation (alloHSCT). The supportive therapy in patients after alloHSCT includes especially ultraviolet protection and the use of emollients.

Aim
Due to the lack of studies regarding epidermal barrier function in patients with alloHSCT, our aims were to monitor dermatologically patients one year after the procedure with special emphasis on epidermal barrier function and to evaluate the properties of epidermal barrier function in patients with confirmed chronic GvHD (cGvHD).

Material and methods
Our pilot study included 30 patients after alloHSCT and 20 healthy controls. In the group of patients after alloHSCT there were 10 individuals who were monitored dermatologically (including evaluation of skin, mucosae, nails and hair) within 1 year after the procedure (subgroup 1) and 20 patients with previously confirmed cGvHD (subgroup 2). We evaluated transepidermal water loss (TEWL), skin hydration and skin color. The clinical assessment and all noninvasive evaluations in patients included in subgroup 1 were performed before (at baseline) and 3, 6, 9 and 12 months after the procedure, while in subgroup 2 they were performed once.

Results
In subgroup 1 we did not observe significant differences between baseline results and periods of assessments in TEWL values or corneometry, erythema and melanin measurements. In subgroup 2 the highest TEWL values and the lowest corneometry results were observed in patients with sclerodermoid chronic cutaneous GvHD in comparison to patients with lichenoid chronic cutaneous GvHD and patients with cGvHD but without skin lesions. TEWL values and melanin level were significantly higher in patients with cGvHD than in controls.

Conclusions
Our pioneer observations proved the disturbed epidermal barrier function among patients after alloHSCT. Therefore it seems that proper skin care, including photoprotection, should be recognized as a crucial component in long-term management of these patients.

keywords:

allogeneic hematopoietic stem cell transplantation, epidermal barrier function, transepidermal water loss, transepidermal water loss, corneometry, graft versus host disease
FEATURED PRODUCTS
BOOKS
• Atopowe Zapalenie Skóry • Choroby alergiczne w praktyce lekarza rodzinnego • Alergologia – kompendium
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.