Etiopathogenetic factors, thyroid functions and thyroid autoimmunity in melasma patients

Seray Külcü Çakmak; Nimet Özcan; Arzu Kılıç; Suha Koparal; Ferda Artüz; Atıl Çakmak; Kenan Köse

doi:10.5114/pdia.2015.54742

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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5/2015
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abstract:

Original paper

Etiopathogenetic factors, thyroid functions and thyroid autoimmunity in melasma patients

Seray Külcü Çakmak

,

Nimet Özcan

,

Arzu Kılıç

,

Suha Koparal

,

Ferda Artüz

,

Atıl Çakmak

,

Kenan Köse

Postep Derm Alergol 2015; XXXII (5): 327–330

DOI: https://doi.org/10.5114/pdia.2015.54742

Online publish date: 2015/10/29

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Introduction: Melasma is a common chronic, acquired pigmentation disorder with a significant impact on the quality of life of patients.

Aim: To investigate the etiopathogenetic factors, thyroid functions and thyroid autoimmunity in patients with melasma.

Material and methods: Forty-five women with melasma and 45 age-matched healthy women were included in the study group. A detailed history was taken from the patients including triggering factors of melasma. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), anti-thyroglobulin (AbTG) and anti-thyroid peroxidase (Ab-TPO) were measured and thyroid ultrasonography was performed for each subject.

Results: In 26.7% of patients, pregnancy, in 17.8%, oral contraceptive use and in 13.3%, intense sunlight exposure were the triggering factors. 17.8% of patients had a family history of melasma. FT4, TSH and AbTG levels were significantly higher in the patient group.

Conclusions: The results suggest that a combination of factors including pregnancy, oral contraceptive use, sunlight and genetic factors often trigger melasma. Thyroid hormones and thyroid autoimmunity may also play a role in the pathogenesis which needs to be proven by further studies.

keywords:

Etiopathogenetic factors, thyroid functions and thyroid autoimmunity in melasma patients

Seray Külcü Çakmak , Nimet Özcan , Arzu Kılıç , Suha Koparal , Ferda Artüz , Atıl Çakmak , Kenan Köse

melasma, thyroid, etiopathogenesis

Seray Külcü Çakmak

,

Nimet Özcan

,

Arzu Kılıç

,

Suha Koparal

,

Ferda Artüz

,

Atıl Çakmak

,

Kenan Köse