eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2022
vol. 47
 
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abstract:
Clinical immunology

Evaluation of immunological abnormalities in patients with rare syndromes

Yahya Gul
1
,
Hasan Kapakli
2
,
Selma Erol Aytekin
1
,
Şukru Nail Guner
1
,
Sevgi Keles
1
,
Ayşe Gül Zamani
3
,
Mahmut Selman Yildirim
3
,
Ïsmail Reisli
1

  1. Necmettin Erbakan University, Meram Medical School, Division of Pediatric Allergy and Immunology, Konya, Turkey
  2. Ballkesir City Hospital, Pediatric Allergy and Immunology Clinic, Ballkesir, Turkey
  3. Necmettin Erbakan University, Meram Medical School, Department of Medical Genetics, Konya, Turkey
Cent Eur J Immunol 2022; 47 (4): 299-307
DOI: https://doi.org/10.5114/ceji.2022.124080
Online publish date: 2023/01/31
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Introduction:
Recurrent infections are important problems in syndromic patients. This study aimed to evaluate immunological abnormalities in patients who presented with recurrent infections and were diagnosed with rare syndromes.

Material and methods:
This retrospective analysis included 14 patients with complaints of recurrent infections, all of whom were diagnosed with a rare syndrome.

Results:
The study group consisted of patients with Aicardi syndrome, Brugada syndrome, Phelan- McDermid syndrome, trichothiodystrophy, LEOPARD syndrome, Prader-Willi syndrome, Seckel syndrome, trisomy 18 (Edwards’ syndrome), Wiedemann-Steiner syndrome, West syndrome, Williams syndrome, 47,XYY syndrome, 16p13 deletion syndrome, and 13q1.3 deletion syndrome. Seven patients (50%) were girls and seven (50%) were boys (mean age, 56.7 ±32.9 months; median [range] age: 45.5 [27-153] months). There were high rates of consanguinity (50%), cesarean section delivery (71%), and hospitalization in the intensive care unit (78.5%). No patients had a family history of immunodeficiency. On admission, all patients exhibited humoral and/or cellular immune system abnormalities. During the follow-up period, all T-cell abnormalities were improved after immunoglobulin replacement therapy (IGRT), while B-cell abnormalities persisted. These findings suggested that the patients predominantly had antibody deficiencies associated with mild T-cell abnormalities because of recurrent infections. The rates of infections and hospitalizations were significantly reduced after IGRT (p < 0.001); the rate of intensive care unit admission also significantly decreased (from 78.5% to 21.4%). Two of the three oxygen-dependent patients exhibited improvement therein. IGRT was discontinued in two patients with significant clinical improvement during follow-up.

Conclusions:
An immunological evaluation should be considered in pediatric patients with rare syndromes and recurrent infections. IGRT may help to improve the prognoses of these patients.

keywords:

immunodeficiency, rare syndrome, recurrent infection, immunoglobulin replacement therapy
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