Evaluation of interleukin 8 polymorphisms (-251T/A and +781C/T) in patients with hepatocellular carcinoma: a meta-analysis

Omid Emami Aleagha; Forouzan Moeinzadeh; Seyedeh Farnaz Moeini Shokouh; Erkan Doğan; Masoud Sadeghi

doi:10.5114/ceh.2021.109424

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Evaluation of interleukin 8 polymorphisms (-251T/A and +781C/T) in patients with hepatocellular carcinoma: a meta-analysis

Omid Emami Aleagha

^{1, 2}

,

Forouzan Moeinzadeh

³

,

Seyedeh Farnaz Moeini Shokouh

³

,

Erkan Doğan

⁴

,

Masoud Sadeghi

⁵

Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
Department of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Iran
Department of Pediatrics, Karabuk University, Faculty of Medicine, Karabuk, Turkey
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Clin Exp HEPATOL 2021; 7, 3: 278-285

DOI: https://doi.org/10.5114/ceh.2021.109424

Online publish date: 2021/10/12

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Introduction
We reported the association between interleukin 8 (IL-8) polymorphisms (-251T/A and +781C/T) and hepatocellular carcinoma (HCC) risk in a meta-analysis.

Material and methods
Scopus, PubMed, Web of Science, and Cochrane Library databases were searched until 21 November 2020. The analyses were performed by RevMan 5.3 software using odds ratios (ORs) and 95% confidence intervals (CIs). Also, the analysis of publication bias was performed by CMA 2.0 software.

Results
Searching databases/sources, five articles including ten studies were entered into the meta-analysis. The pooled ORs for -251T/A polymorphism were 1.07 (p = 0.55), 1.04 (p = 0.75), 1.31 (p = 0.24), 1.24 (p = 0.31), and 1.85 (p = 0.29) for allele, homozygote, heterozygote, recessive and dominant models, respectively. With regards to +781C/T polymorphism, the pooled ORs were 0.74 (p = 0.07), 0.53 (p = 0.03), 0.83 (p = 0.41), 0.75 (p = 0.19), and 0.57 (p = 0.02) for allele, homozygote, heterozygote, recessive, and dominant models, respectively.

Conclusions
The findings of the meta-analysis showed a lack of significant association between IL-8 (-251T/A) polymorphism and the HCC risk, whereas the TT genotype of IL-8 (+781C/T) polymorphism had a protective role in HCC.

keywords:

Evaluation of interleukin 8 polymorphisms (-251T/A and +781C/T) in patients with hepatocellular carcinoma: a meta-analysis

Omid Emami Aleagha 1, 2 , Forouzan Moeinzadeh 3 , Seyedeh Farnaz Moeini Shokouh 3 , Erkan Doğan 4 , Masoud Sadeghi 5

hepatocellular carcinoma, interleukin 8, liver cancer, polymorphism

Omid Emami Aleagha

^{1, 2}

,

Forouzan Moeinzadeh

³

,

Seyedeh Farnaz Moeini Shokouh

³

,

Erkan Doğan

⁴

,

Masoud Sadeghi

⁵