Evaluation of outcome and prognostic factors in 739 patients with uterine cervix carcinoma: a single institution experience

Fatma Teke; Adnan Yöney; Memik Teke; Gültekin Adanaș; Zuhat Urakçı; Gül Türkcü; Bekir Eren; Ali İnal; Mustafa Ünsal

doi:10.5114/wo.2015.51418

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2015
vol. 19

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abstract:

Original paper

Evaluation of outcome and prognostic factors in 739 patients with uterine cervix carcinoma: a single institution experience

Fatma Teke

,

Adnan Yöney

,

Memik Teke

,

Gültekin Adanaș

,

Zuhat Urakçı

,

Gül Türkcü

,

Bekir Eren

,

Ali İnal

,

Mustafa Ünsal

Contemp Oncol (Pozn) 2015; 19 (2): 130–136

DOI: https://doi.org/10.5114/wo.2015.51418

Online publish date: 2015/05/13

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Aim of the study: The aim of this retrospective chart review was to determine the long-term outcomes and identify prognostic factors that impact the survival of patients with cervical cancer.

Material and methods: A retrospective chart review of 739 patients with International Federation of Gynaecology and Obstetrics (FIGO) stage I–IV cervical cancer treated with surgery, radiation or chemoradiation was performed. Patient charts were evaluated in terms of demographics, clinical outcomes, and survival. Disease-free survival (DFS) and overall survival (OS) were calculated with the Kaplan-Meier method, and differences in survival were compared with the log-rank test. Multivariate analysis was performed with a Cox proportional hazards model to determine the estimated hazard ratios (HR) with 95% confidence intervals (CI) for each prognostic factor.

Results: The Cox proportional hazards model demonstrated that pelvic nodal metastasis (p = 0.018), parametrial invasion (p = 0.015), and presence of disease in the surgical margin (p = 0.011) were all independent prognostic factors for OS. The 5-year OS rate of patients with negative pelvic lymph nodes was 67.1%, which was higher than the rate for those with positive nodes at 49.0% (p < 0.05). The 5-year OS rate was 54.3% for patients with metastasis to the parametrium, 79.2% with a cancer-free parametrium, 60.9% with a cancer-positive surgical margin, 85.4% with a cancer-negative surgical margin, and 64.3% with a 1–3 mm close surgical margin (p < 0.05).

Conclusions: Assessing pelvic lymph nodes, the parametrium, and surgical margins is important for survival and may aid in better identifying patients who would derive greater benefits from receiving adjuvant therapies and more aggressive treatments.

keywords:

Evaluation of outcome and prognostic factors in 739 patients with uterine cervix carcinoma: a single institution experience

Fatma Teke , Adnan Yöney , Memik Teke , Gültekin Adanaș , Zuhat Urakçı , Gül Türkcü , Bekir Eren , Ali İnal , Mustafa Ünsal

cervical cancer, parametrial invasion, pelvic lymph node, prognostic factors, survival

Fatma Teke

,

Adnan Yöney

,

Memik Teke

,

Gültekin Adanaș

,

Zuhat Urakçı

,

Gül Türkcü

,

Bekir Eren

,

Ali İnal

,

Mustafa Ünsal