Evaluation of oxaliplatin-induced pulmonary toxicity in rats

Serdar Kalemci; Ozgür Tanrıverdi; Abdullah Şimşek; Saliha Aksun; Ozgür Celik; Sabri Barutca; Arife Zeybek; Buket Demirci

doi:10.5114/wo.2019.89242

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2019
vol. 23

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abstract:

Original paper

Evaluation of oxaliplatin-induced pulmonary toxicity in rats

Serdar Kalemci

¹

,

Ozgür Tanrıverdi

²

,

Abdullah Şimşek

³

,

Saliha Aksun

⁴

,

Ozgür I. Celik

⁵

,

Sabri Barutca

⁶

,

Arife Zeybek

⁷

,

Buket Demirci

⁸

Department of Chest Diseases, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey
Department of Medical Oncology, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey
Department of Chest Diseases, Sağlık Bilimleri University, Yüksek İhtisas Education and Research Hospital, Bursa, Turkey
Department of Medical Biochemistry, Faculty of Medicine, Katip Celebi University, Izmir, Turkey
Department of Pathology, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey
Department of Medical Oncology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey
Department of Thoracic Surgery, Faculty of Medicine, Sitki Kocman University, Mugla, Turkey
Department of Medical Pharmacology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey

Contemp Oncol (Pozn) 2019; 23 (3): 151-156

DOI: https://doi.org/10.5114/wo.2019.89242

Online publish date: 2019/10/31

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Introduction
The mechanism of oxaliplatin (OXA) induced pulmonary toxicity is not fully understood.

Aim of the study
The present study was designed to investigate the pulmonary toxicity of OXA that has been reported in previous studies. Study design: animal experiments.

Material and methods
A total of 40 female Wistar rats were divided into 5 groups. In group 1, 5% glucose was injected intra-peritoneally; then the rats were sacrificed on day 14. OXA was administered in groups 2, 3, 4, and 5; then the animals were sacrificed on day 7 in group 2, day 14 in group 3, day 28 in group 4 and day 48 in group 5. The groups were further categorized as short-term administration and long-term administration groups. Furthermore, tissue glutathione peroxidase (GPX) activity was measured in all rats.

Results
The mean GPX activities were 0.66 U/mg in the sham group, 0.74 U/mg in the short-term groups, and 0.74 U/mg in the long-term groups. We found that long-term OXA administration causes pulmonary toxicity resulting in increased intra-alveolar/interstitial macrophages and interstitial pneumonia. Similarly, we found reduced and permanent tissue GPX activity in rats that received OXA in higher doses and for a long term.

Conclusions
Long-term OXA therapy causes toxic changes in the lung tissue.

keywords:

Evaluation of oxaliplatin-induced pulmonary toxicity in rats

Serdar Kalemci 1 , Ozgür Tanrıverdi 2 , Abdullah Şimşek 3 , Saliha Aksun 4 , Ozgür I. Celik 5 , Sabri Barutca 6 , Arife Zeybek 7 , Buket Demirci 8

glutathione peroxidase, oxaliplatin, pulmonary toxicity, rat, pulmonary pathology

Serdar Kalemci

¹

,

Ozgür Tanrıverdi

²

,

Abdullah Şimşek

³

,

Saliha Aksun

⁴

,

Ozgür I. Celik

⁵

,

Sabri Barutca

⁶

,

Arife Zeybek

⁷

,

Buket Demirci

⁸