Evaluation of protein tyrosine phosphatase activity in patients with  	acute leukemia

Elif Akdogan; Sevil Cengiz; Mustafa Yılmaz; Mehmet Sönmez; Ahmet Durmus; Ercüment Oval; Serdar Bedii Omay

doi:10.5114/wo.2013.33780

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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1/2013
vol. 17

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abstract:

Original paper

Evaluation of protein tyrosine phosphatase activity in patients with acute leukemia

Elif Akdogan

,

Sevil Cengiz

,

Mustafa Yılmaz

,

Mehmet Sönmez

,

Ahmet Durmus

,

Ercüment Oval

,

Serdar Bedii Omay

Wspolczesna Onkol 2013; 17 (1): 83–87

DOI: https://doi.org/10.5114/wo.2013.33780

Online publish date: 2013/03/15

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Protein tyrosine phosphatases regulate physiological processes including growth, differentiation, metabolism and the cell cycle. Together with tyrosine kinases, they control the phosphorylation state of tyrosine residues of signaling proteins. An increased level of protein phosphorylation results in abnormal proliferation and many cancer types show a mutation or deletion of a protein tyrosine phosphatase gene. In this study we evaluated the protein tyrosine phosphatase activity in acute leukemia patients. Tyrosine phosphatase activity in bone marrow mononuclear cells of acute leukemia patients was measured using a tyrosine phosphatase assay system kit and compared with a control group. We found that tyrosine phosphatase activity in acute leukemia patients was high compared to the controls. According to subgroups of acute leukemia, tyrosine phosphatase activity in the AML-M2 subgroup was high compared to the controls. The effect of increased level of protein tyrosine phosphatase activity on leukemogenesis needs further evaluation. Studies in a large group of patients are needed to emphasize the importance of tyrosine phosphatase activity in acute leukemia patients.

keywords:

Evaluation of protein tyrosine phosphatase activity in patients with acute leukemia

Elif Akdogan , Sevil Cengiz , Mustafa Yılmaz , Mehmet Sönmez , Ahmet Durmus , Ercüment Oval , Serdar Bedii Omay

tyrosine phosphatase activity, acute leukemia

Elif Akdogan

,

Sevil Cengiz

,

Mustafa Yılmaz

,

Mehmet Sönmez

,

Ahmet Durmus

,

Ercüment Oval

,

Serdar Bedii Omay