Evaluation of the role of YKL-40 in psoriasis and its connection
to metabolic syndrome

Heba A.S. Bazid; Manar Helmy; Eman M. Abd El Gayed; Shaimaa Abdelhamid Hassanein; Rania Abdallah Abdallah; Iman Seleit

doi:10.5114/dr.2024.149030

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2024
vol. 111

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abstract:

Original article

Evaluation of the role of YKL-40 in psoriasis and its connection to metabolic syndrome

Heba A.S. Bazid

¹

,

Manar Helmy

¹

,

Eman M. Abd El Gayed

²

,

Shaimaa Abdelhamid Hassanein

³

,

Rania Abdallah Abdallah

⁴

,

Iman Seleit

¹

Dermatology and Andrology Department, Faculty of Medicine, Menoufia University, Egypt
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Egypt
Diagnostic and Interventional Radiology and Medical lmaging, Faculty of Medicine, Menoufia University, Egypt
Pathology Department, Faculty of Medicine, Menoufia University, Egypt

Dermatol Rev/Przegl Dermatol 2024, 111, 334-346

DOI: https://doi.org/10.5114/dr.2024.149030

Online publish date: 2025/02/25

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Introduction:
Psoriasis is a prevalent skin inflammatory disorder with immune-mediated pathogenesis. Chitinase-3 like-protein-1 (YKL-40) is a glycoprotein with elevated expression levels in many human cancers and inflammatory diseases.

Objective:
The YKL-40 expression levels in psoriasis patients’ serum and skin tissue were investigated and compared with the patient’s clinical and histological information and metabolic syndrome variables.

Material and methods:
Enzyme-linked immunosorbent assay along with immunohistochemistry were performed to assess serum and tissue expression of YKL-40, respectively, in 35 psoriasis patients and 35 healthy controls. Moreover, carotid intima-media thickness and metabolic syndrome parameters were evaluated.

Results:
Patients with psoriasis had considerably increased serum and tissue expression of YKL-40 in comparison to healthy individuals. These levels in tissue and serum correlated with each other. YKL-40 immunohistochemical expression was also linked to elevated lipid profiles in psoriatic patients.

Conclusions:
As YKL-40 tissue expression was associated with the essential pathologic changes of psoriasis (increased cutaneous vascularity and inflammation), YKL-40 appeared to have a promising future in psoriasis. Furthermore, its association with elevated lipid profile in those patients suggests that YKL-40 may play a role in psoriasis and metabolic symdrome development. The elevated serum level was higher in patients and positively correlated to its tissue expression.

keywords:

psoriasis, metabolic syndrome, YKL-40

Indeks osobowy

Evaluation of the role of YKL-40 in psoriasis and its connection to metabolic syndrome

Heba A.S. Bazid 1 , Manar Helmy 1 , Eman M. Abd El Gayed 2 , Shaimaa Abdelhamid Hassanein 3 , Rania Abdallah Abdallah 4 , Iman Seleit 1

psoriasis, metabolic syndrome, YKL-40

Heba A.S. Bazid

¹

,

Manar Helmy

¹

,

Eman M. Abd El Gayed

²

,

Shaimaa Abdelhamid Hassanein

³

,

Rania Abdallah Abdallah

⁴

,

Iman Seleit

¹