Evaluation of total sulfhydryl levels and dietary habits in pemphigus vulgaris

Goknur Yavuz; Nazlı Caf; Mustafa Tümtürk; Mehmet Onur Gökalp; Halit Demir; Canan Demir; Mustafa Bilici

doi:10.5114/ada.2024.147196

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Evaluation of total sulfhydryl levels and dietary habits in pemphigus vulgaris

Goknur Ozaydın Yavuz

¹

,

Nazlı Caf

²

,

Mustafa Tümtürk

²

,

Mehmet Onur Gökalp

³

,

Halit Demir

⁴

,

Canan Demir

⁵

,

Mustafa Bilici

⁶

Department of Dermatology, Health Sciences University, Istanbul, Turkey
Department of Dermatology, Atlas University, Istanbul, Turkey
Department of Dermatology, Cam and Sakura City Hospital, Istanbul, Turkey
Department of Chemistry, Yuzuncu Yil University, Faculty of Science and Art, Van, Turkey
Medical Documentation and Secretary, Yuzuncu Yil University, Vocational School of Health Services, Van, Turkey
Department of Basic Medical Sciences, Yuzuncu Yil University Faculty of Medicine, Van, Turkey

Adv Dermatol Allergol

DOI: https://doi.org/10.5114/ada.2024.147196

Online publish date: 2025/01/31

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Introduction:
Pemphigus vulgaris (PV) is a rare autoimmune bullous dermatitis caused by autoantibodies against desmoglein-1 and desmoglein-3. Sulfhydryl group/total thiols play a key role in numerous cellular activities, such as antioxidant protection, detoxification, cell growth, and apoptosis. Acantholysis may develop due to chemical reasons.

Aim:
The aim of this study was to investigate the relationship between PV and serum total sulfhydryl levels.

Material and methods:
The study was conducted with a total of 177 individuals, comprising 86 PV patients and 91 controls. Age, gender, smoking status, alcohol consumption, and pemphigus-triggering food intake were recorded. Diagnosis of PV was established based on the clinical and histopathologic examinations followed by a direct immunofluorescence and indirect immunofluorescence test. Serum total sulfhydryl level (TSH) was measured by spectrophotometric method.

Results:
Mean age was 41.94 ±11.41 years in the patient group and 39.86 ±11.72 years in the control group. In the PV group, smoking was noted in 62.8% (n = 54) and alcohol consumption was noted in 32.6% (n = 28) of the patients. There was a significant difference in total sulfhydryl levels between the groups.

Conclusions:
Our findings suggest that foods and drugs containing sulfhydryl groups may induce pemphigus vulgaris or aggravate the disease.

keywords:

Evaluation of total sulfhydryl levels and dietary habits in pemphigus vulgaris

Goknur Ozaydın Yavuz 1 , Nazlı Caf 2 , Mustafa Tümtürk 2 , Mehmet Onur Gökalp 3 , Halit Demir 4 , Canan Demir 5 , Mustafa Bilici 6

diet, pemphigus, sulfhydryl

Goknur Ozaydın Yavuz

¹

,

Nazlı Caf

²

,

Mustafa Tümtürk

²

,

Mehmet Onur Gökalp

³

,

Halit Demir

⁴

,

Canan Demir

⁵

,

Mustafa Bilici

⁶