Examination of the activity of chosen blood platelets lysosomal proteases in atopic dermatitis patients

In this study the activity of lysosomal hydrolases of blood platelets was analyzed. Catepsin G, B, D and tiolic katepsin were designated. The results of the investigations were statistically estimated. 67 patients with atopic dermatitis and healthy controls were examined. They were divided into two groups depending on the severity degree of the symptoms of atopic dermatitis (SCORAD). The study of the enzymatic activity in both groups differed significantly. In patients with significant degree of intensification of the disease process (SCORAD above 40) the decrease in catepsin G was observed, together with the increase in activity of catepsins D i B. The activity of those enzymes may determine the degree of the severity of atopic dermatitis. It is suggested that the defect in the process of synthesis and activation of lysosomal enzymes may be one of the reasons of the onset and development of atopic dermatitis.
Despite of multidirectional research of atopic dermatitis, the etiopathogenesis has not been revealed so far. Until recently we have emphasized the role of hydrolytic lysosome enzymes and platelets in the course of chronic inflammatory processes to which atopic dermatitis also belongs. In the contemporary methods of atopic dermatitis treatment mechanisms associated with stabilization of lysosomal membranes of the platelets should be taken into consideration.