Experimental immunology<br>A novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients

Yuki Nanke; Toru Yago; Tsuyoshi Kobashigawa; Manabu Kawamoto; Hisashi Yamanaka; Shigeru Kotake

doi:10.5114/ceji.2014.47730

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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4/2014
vol. 39

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abstract:

Experimental immunology
A novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients

Yuki Nanke

,

Toru Yago

,

Tsuyoshi Kobashigawa

,

Manabu Kawamoto

,

Hisashi Yamanaka

,

Shigeru Kotake

(Centr Eur J Immunol 2014; 39 (4): 468-470)

DOI: https://doi.org/10.5114/ceji.2014.47730

Online publish date: 2014/12/15

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AMA

Nanke Y, Yago T, Kobashigawa T, Kawamoto M, Yamanaka H, Kotake S. Experimental immunologyA novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients. Central European Journal of Immunology. 2014;39(4):468-470. doi:10.5114/ceji.2014.47730.

APA

Nanke, Y., Yago, T., Kobashigawa, T., Kawamoto, M., Yamanaka, H.,  & Kotake, S. (2014). Experimental immunologyA novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients. Central European Journal of Immunology, 39(4), 468-470. https://doi.org/10.5114/ceji.2014.47730

Chicago

Nanke, Yuki, Toru Yago, Tsuyoshi Kobashigawa, Manabu Kawamoto, Hisashi Yamanaka,  and Shigeru Kotake. 2014. "Experimental immunologyA novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients". Central European Journal of Immunology 39 (4): 468-470. doi:10.5114/ceji.2014.47730.

Harvard

Nanke, Y., Yago, T., Kobashigawa, T., Kawamoto, M., Yamanaka, H.,  and Kotake, S. (2014). Experimental immunologyA novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients. Central European Journal of Immunology, 39(4), pp.468-470. https://doi.org/10.5114/ceji.2014.47730

MLA

Nanke, Yuki et al. "Experimental immunologyA novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients." Central European Journal of Immunology, vol. 39, no. 4, 2014, pp. 468-470. doi:10.5114/ceji.2014.47730.

Vancouver

Nanke Y, Yago T, Kobashigawa T, Kawamoto M, Yamanaka H, Kotake S. Experimental immunologyA novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients. Central European Journal of Immunology. 2014;39(4):468-470. doi:10.5114/ceji.2014.47730.

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Background: We have demonstrated that a peptide, which we named ‘Peptide A’, derived from the extracellular domain of T-cell leukemia translocation-associated gene (TCTA) protein, inhibited human osteoclastogenesis.

Objective: In the current study, we examined whether this peptide inhibits the proliferation of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) or not.

Material and methods: Fibroblast-like synoviocytes obtained from five RA patients were cultured in the absence or presence of 1, 5, 10 µg/ml of peptide. We used 29-mer scrambled peptide as a control.

Results: The peptide inhibited the proliferation of RA FLS dose-dependently. On the other hand, the scrambled peptide showed no inhibition.

Conclusions: The peptide inhibits both human osteoclastogenesis and the proliferation of RA FLS. Thus, the peptide may be used for the therapy of both osteoporosis and synovitis of RA patients.

This is the first report of the new peptide we discovered, which inhibits both osteoclastogenesis and synovitis. Thus, this new peptide could be a new drug for patients with both osteoporosis and RA.

keywords:

Experimental immunologyA novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients

Yuki Nanke , Toru Yago , Tsuyoshi Kobashigawa , Manabu Kawamoto , Hisashi Yamanaka , Shigeru Kotake

osteoclast, arthritis, synovium, translocation-associated gene (TCTA), T-cell leukemia

Experimental immunology
A novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients

Yuki Nanke

,

Toru Yago

,

Tsuyoshi Kobashigawa

,

Manabu Kawamoto

,

Hisashi Yamanaka

,

Shigeru Kotake