Experimental immunology<br>A preliminary report on predicted epitopes of malarial VAR2CSA by bioinformatics method: a clue for further vaccine development

Viroj Wiwanitkit

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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3/2007
vol. 32

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abstract:

Experimental immunology
A preliminary report on predicted epitopes of malarial VAR2CSA by bioinformatics method: a clue for further vaccine development

Viroj Wiwanitkit

Centr Eur J Immunol 2007; 32 (3): 169-171

Online publish date: 2007/09/10

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Malaria is an important tropical infection. Development and approval of new vaccines are the hope for infectious control of the possible emerging pandemic of this pathogen. Malarial VAR2CSA may have value as a protective immunogen in novel vaccines. Here, the author reports the preliminary data from the computation analysis of VAR2CSA to find potential T-cell and B-cell epitopes using new bioinformatics tools. According to this work, the possible alternatives are reported. These data are useful for further vaccine development because these promiscuous peptide binders allows to minimize the total number of predicted epitopes without compromising the population coverage required in the design of vaccines.

keywords:

Experimental immunologyA preliminary report on predicted epitopes of malarial VAR2CSA by bioinformatics method: a clue for further vaccine development

Viroj Wiwanitkit

malaria, VAR2CSA

Experimental immunology
A preliminary report on predicted epitopes of malarial VAR2CSA by bioinformatics method: a clue for further vaccine development