Experimental immunology<br>Bacterial lipoprotein tolerance attenuates cardiac dysfunction in septic mice

Jing Zhou; Min Huang; Li-Qing Bi; Su-Ming Zhou; Yun-Lin Cheng; Guo-Xian Ding; Wei-Hao Sun

doi:10.5114/ceji.2012.30796

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

3/2012
vol. 37

Send email

Copy url:

abstract:

Experimental immunology
Bacterial lipoprotein tolerance attenuates cardiac dysfunction in septic mice

Jing Zhou

,

Min Huang

,

Li-Qing Bi

,

Su-Ming Zhou

,

Yun-Lin Cheng

,

Guo-Xian Ding

,

Wei-Hao Sun

(Centr Eur J Immunol 2012; 37 (3): 209-220)

DOI: https://doi.org/10.5114/ceji.2012.30796

Online publish date: 2012/10/27

View full text Get citation

PlumX metrics:

In order to examine the effect of BLP tolerance on cardiac dysfunction in CLP-induced septic mice, cardiac function was measured via echocardiography at various time points following induction of sepsis by CLP in BLP-tolerant and control C57BL/6 mice. Levels of tumour necrosis factor α (TNF-α), interleukin 10 (IL-10) and Toll-like receptor 2 (TLR2)-myeloid differentiation factor 88 (MyD88)-dependent signaling molecules in the myocardium were also examined. Cardiac function was significantly decreased 6-12 h following CLP-induced sepsis compared with that of sham controls, with cardiac output decreasing from 0.50 ±0.06 ml/s to 0.16 ±0.04 ml/s at 6 h and 0.57 ±0.06 ml/s to 0.13 ±0.02 ml/s at 12 h, whereas BLP tolerance attenuated CLP-induced cardiac dysfunction at 12 h following CLP with cardiac output increasing from 0.13 ±0.02 ml/s to 0.26 ±0.05 ml/s at 12 h. TNF-α, IL-10 and TLR2-MyD88-dependent signaling molecules in the myocardium were not significantly different among BLP-tolerant or non-tolerant control groups. These findings suggest that low dose BLP pretreatment can attenuate cardiac dysfunction, increasing the survival rate of septic mice. This effect did not involve TNF-α, IL-10 or TLR2-MyD88-dependent cytokines. Bacterial lipoprotein pretreatment attenuated cardiac dysfunction in CLP sepsis. TNF-α, IL-10 and TLR2-MyD88-dependent signaling molecules did not contribute to cardiac dysfunction observed in CLP-induced sepsis.

keywords:

Experimental immunologyBacterial lipoprotein tolerance attenuates cardiac dysfunction in septic mice

Jing Zhou , Min Huang , Li-Qing Bi , Su-Ming Zhou , Yun-Lin Cheng , Guo-Xian Ding , Wei-Hao Sun

cardiac dysfunction, bacterial lipoprotein, Toll-like receptor 2, sepsis

Experimental immunology
Bacterial lipoprotein tolerance attenuates cardiac dysfunction in septic mice

Jing Zhou

,

Min Huang

,

Li-Qing Bi

,

Su-Ming Zhou

,

Yun-Lin Cheng

,

Guo-Xian Ding

,

Wei-Hao Sun