Experimental immunology

Diminished reactive oxygen intermediates (ROI) production, decreased the T suppressor cells number and increased cytokine production constitute outline of the lichen sclerosus pathogenesis

Abstract

The involution of lichen sclerosus (LS) affected tissues may be the effect of suppression exerted by T lymphocytes which are involved in the pathogenesis of this disease. Inflammatory infiltrates in the affected regions of the skin consist mainly of CD3+ lymphocytes consist with diminished number of CD3+/CD26+ subsets. We revealed the diminished ROI production by peripheral blood, granulocytes after receptor dependent and receptor independent stimulation. The diminished number both of CD3+/CD25+ and CD3+/CD26+ in peripheral blood baseline increase of IL-12 and stimulated increase of IL-2, IL-5, IL-10 and TNF-α production by peripheral blood lymphocytes were also noted. We postulate that immunereactions are involved in LS pathogenesis.

Key wo
Abstract
The involution of lichen sclerosus (LS) affected tissues may be the effect of suppression exerted by T lymphocytes which are involved in the pathogenesis of this disease. Inflammatory infiltrates in the affected regions of the skin consist mainly of CD3+ lymphocytes consist with diminished number of CD3+/CD26+ subsets. We revealed the diminished ROI production by peripheral blood, granulocytes after receptor dependent and receptor independent stimulation. The diminished number both of CD3+/CD25+ and CD3+/CD26+ in peripheral blood baseline increase of IL-12 and stimulated increase of IL-2, IL-5, IL-10 and TNF-α production by peripheral blood lymphocytes were also noted. We postulate that immunereactions are involved in LS pathogenesis.