Experimental immunology<br>The effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema

Viktoriya Milanova; Nina Ivanovska; Petya Dimitrova

doi:10.5114/ceji.2014.43712

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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2/2014
vol. 39

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abstract:

Experimental immunology
The effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema

Viktoriya Milanova

,

Nina Ivanovska

,

Petya Dimitrova

(Centr Eur J Immunol 2014; 39 (2): 131–141)

DOI: https://doi.org/10.5114/ceji.2014.43712

Online publish date: 2014/06/27

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AMA

Milanova V, Ivanovska N, Dimitrova P. Experimental immunologyThe effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema. Central European Journal of Immunology. 2014;39(2):131-141. doi:10.5114/ceji.2014.43712.

APA

Milanova, V., Ivanovska, N.,  & Dimitrova, P. (2014). Experimental immunologyThe effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema. Central European Journal of Immunology, 39(2), 131-141. https://doi.org/10.5114/ceji.2014.43712

Chicago

Milanova, Viktoriya, Nina Ivanovska,  and Petya Dimitrova. 2014. "Experimental immunologyThe effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema". Central European Journal of Immunology 39 (2): 131-141. doi:10.5114/ceji.2014.43712.

Harvard

Milanova, V., Ivanovska, N.,  and Dimitrova, P. (2014). Experimental immunologyThe effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema. Central European Journal of Immunology, 39(2), pp.131-141. https://doi.org/10.5114/ceji.2014.43712

MLA

Milanova, Viktoriya et al. "Experimental immunologyThe effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema." Central European Journal of Immunology, vol. 39, no. 2, 2014, pp. 131-141. doi:10.5114/ceji.2014.43712.

Vancouver

Milanova V, Ivanovska N, Dimitrova P. Experimental immunologyThe effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema. Central European Journal of Immunology. 2014;39(2):131-141. doi:10.5114/ceji.2014.43712.

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We investigated the effect of interleukin (IL)-17 on Ly6G+ cell apoptosis in zymosan-induced arthritis (ZIA) and oedema (ZIO). Zymosan injection at the ankle joint caused swelling and coincided with histological joint alterations and IL-17A expression in areas with cell infiltrates. Flow cytometry of blood demonstrated increased frequencies of Ly6G+CD11b+ cells and their decreased apoptosis in ZIA. Annexin V+ neutrophils had lower CD11b expression, unlike Annexin V– cells. Cell survival for 12 hours was affected neither by IL-17 nor by zymosan alone, while both stimuli diminished Annexin V+ cell frequencies and up-regulated CD11b on Annexin V– cells. Interleukin 17 antagonised to the effects of zymosan in 24-hour cultures. The administration of IL-17 in ZIO increased paw thickness, enlarged the blood Ly6G+ pool, elevated CD11b expression and decreased apoptosis. We suggest that altered neutrophil apoptosis in arthritis can be overcome by anti-IL-17 therapy combined with an inhibition of Toll-like receptor (TLR) 2 and CD11b signalling.

keywords:

Experimental immunologyThe effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema

Viktoriya Milanova , Nina Ivanovska , Petya Dimitrova

neutrophils, CD11b, interleukin 17, neutrophils, TLR2 ligand, paw oedema

Experimental immunology
The effect of interleukin 17 and Toll-like receptor 2 on CD11b expression and apoptosis of neutrophils in zymosan-induced arthritis and paw oedema

Viktoriya Milanova

,

Nina Ivanovska

,

Petya Dimitrova