eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2008
vol. 33
 
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abstract:

Experimental immunology
The effect of methylprednisolone on the morphology of rabbit knee joint after partial synovectomy

Leszek Jung
,
Teresa Wagner
,
Michał Mazurkiewicz
,
Ewa Skopińska-Różewska

Centr Eur J Immunol 2008; 33 (4): 176-178
Online publish date: 2008/12/24
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The research was done on 33 rabbits, which underwent partial synovectomy of the right knee. 24 of them were treated with Depo-Medrol twice- immediately after and 7 days after surgery. The knee joints were taken 21 days after surgery, from sacrificed animals, and fixed in formaline. The histological examination of joint cartilage, synovium, fibrous membrane of the joint capsule and muscles of methylprednisolone- treated animals showed the absence of cellular reactions (giant cells and mononuclear cells) in synovium and fibrous membrane. In similar samples from the control group a lot of granulomas were present with foreign-body type giant cells and less or more intense infiltrations of mononuclear cells.
This finding can explain previously reported good functional results of animals injected by Depo-Medrol after knee surgery.
keywords:

rabbit’s knee surgery, methylprednisolone, joint morphology
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