eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2008
vol. 33
 
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abstract:

Experimental immunology
The influence of Rhodiola rosea, Rhodiola kirilowii and Rhodiola quadrifida extracts on cutaneous angiogenesis induced in mice after grafting of human kidney cancer tissue

Ewa Skopińska-Różewska
,
Aleksander Wasiutyński
,
Ewa Sommer
,
Sebastian Mielcarek
,
Alina Mścisz
,
Anna Krajewska-Patan
,
Michał Mazurkiewicz
,
Krzysztof Pastewka

Centr Eur J Immunol 2008; 33 (4): 185-189
Online publish date: 2008/12/24
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The aim of the work was to study the effect of aqueous and 50% hydroalcoholic extracts of Rhodiola rosea, Rhodiola kirilowii and Rhodiola quadrifida roots and rhizomes on neovascular reaction induced in the skin of Balb/c mice after grafting of human kidney cancer tissue homogenate or, for comparison, L-1 sarcoma syngeneic cells. Mice were fed 0.4 mg of extracts daily, for 3 days. After 72 hours mice were sacrificed with lethal dose of Morbital. All newly formed blood vessels were identified and counted in dissection microscope.

Results: Extracts of underground parts of Rhodiola rosea and Rhodiola kirilowii significantly decreased cutaneous neovascular reaction induced by human cancer homogenate, extracts prepared from Rhodiola quadrifida were ineffective in this model of angiogenesis. In syngeneic tumor cells model all extracts were effective, except aqueous extract of R. kirilowii.
keywords:

Angiogenesis, mice, human kidney cancer, Rhodiola rosea, Rhodiola kirilowii, Rhodiola quadrifida
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