Expression and clinical significance of KDM5A, KDM5B, and FOXO1 in endometrial cancer

Yao Gao; Jun Gao

doi:10.5114/pjp.2024.139610

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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2/2024
vol. 75

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abstract:

Original paper

Expression and clinical significance of KDM5A, KDM5B, and FOXO1 in endometrial cancer

Yao Gao

¹

,

Jun Gao

²

Department of Obstetrics and Gynecology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China
Department of Obstetrics and Gynecology, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Clinical Research Center for Cancer, Nanchang, Jiangxi, China

Pol J Pathol 2024; 75 (2): 83-96

DOI: https://doi.org/10.5114/pjp.2024.139610

Online publish date: 2024/05/16

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There is growing evidence that the KDM5 family of histone demethylases plays a causal role in human cancer. However, few studies have been reported on the KDM5 family in endometrial carcinoma (EC). Moreover, it was found that there was some correlation between the KDM5 family and FOXO1 in EC. The current study was performed to explore the expressions of KDM5A, KDM5B, and FOXO1 in endometrioid adenocarcinoma detected by immunohistochemistry; paracancer endometrium, simple hyperplastic endometrium, and normal endometrium were used as control groups to explore the possible diagnostic value of KDM5A and KDM5B expression in endometrioid adenocarcinoma, with the aim of evaluating the potential of this marker in predicting the prognosis of endometrioid adenocarcinoma.

keywords:

Expression and clinical significance of KDM5A, KDM5B, and FOXO1 in endometrial cancer

Yao Gao 1 , Jun Gao 2

endometrioid adenocarcinoma, KDM5A, FOXO1, immunohistochemistry

Yao Gao

¹

,

Jun Gao

²