Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis

Agnieszka Adamczyk; Joanna Niemiec; Aleksandra Ambicka; Krzysztof Małecki; Wojciech H. Wysocki; Jerzy Mituś; Janusz Ryś

doi:10.5114/pjp.2012.32769

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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4/2012
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abstract:

Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis

Agnieszka Adamczyk

,

Joanna Niemiec

,

Aleksandra Ambicka

,

Krzysztof Małecki

,

Wojciech H. Wysocki

,

Jerzy Mituś

,

Janusz Ryś

Pol J Pathol 2012; 63: 228-234

DOI: https://doi.org/10.5114/pjp.2012.32769

Online publish date: 2013/01/24

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AMA

Adamczyk A, Niemiec J, Ambicka A, et al. Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis. Polish Journal of Pathology. 2012;63(4):228-234. doi:10.5114/pjp.2012.32769.

APA

Adamczyk, A., Niemiec, J., Ambicka, A., Małecki, K., Wysocki, W.,  & Mituś, J. et al. (2012). Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis. Polish Journal of Pathology, 63(4), 228-234. https://doi.org/10.5114/pjp.2012.32769

Chicago

Adamczyk, Agnieszka, Joanna Niemiec, Aleksandra Ambicka, Krzysztof Małecki, Wojciech H. Wysocki, Jerzy Mituś,  and Janusz Ryś. 2012. "Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis". Polish Journal of Pathology 63 (4): 228-234. doi:10.5114/pjp.2012.32769.

Harvard

Adamczyk, A., Niemiec, J., Ambicka, A., Małecki, K., Wysocki, W., Mituś, J.,  and Ryś, J. (2012). Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis. Polish Journal of Pathology, 63(4), pp.228-234. https://doi.org/10.5114/pjp.2012.32769

MLA

Adamczyk, Agnieszka et al. "Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis." Polish Journal of Pathology, vol. 63, no. 4, 2012, pp. 228-234. doi:10.5114/pjp.2012.32769.

Vancouver

Adamczyk A, Niemiec J, Ambicka A, Małecki K, Wysocki W, Mituś J et al. Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis. Polish Journal of Pathology. 2012;63(4):228-234. doi:10.5114/pjp.2012.32769.

PlumX metrics:

The immunophenotypic differences between primary and metastatic tumour cells could influence patient’s treatment or/and the results of selected diagnostic procedures.

That prompted us to investigate potential differences between primary tumours and corresponding synchronous lymph node metastases in the T  1/N+/M0 breast cancer patients. The investigated group consisted of 108 patients with invasive ductal breast cancer, who underwent radical surgery. The expression of ER, PR, HER2 as well as CK5/6, P-cadherin, EGFR and Ep-CAM was assessed immunohistochemically.

Our data suggest that ER, PR, HER2, EGFR and CK5/6 are expressed conservatively, with some minor changes between primary tumour and simultaneous lymph node metastases. On the contrary, Ep-CAM and P-cadherin immunoreactivity in primary and metastatic cells varied significantly. This variation might exclude Ep-CAM and P-cadherin as potential diagnostic or therapeutic targets.

keywords:

Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer and in lymph nodes metastases: a comparative immunohistochemical analysis

Agnieszka Adamczyk , Joanna Niemiec , Aleksandra Ambicka , Krzysztof Małecki , Wojciech H. Wysocki , Jerzy Mituś , Janusz Ryś

primary breast tumour, lymph node metastasis, basal markers, adhesion molecules

Agnieszka Adamczyk

,

Joanna Niemiec

,

Aleksandra Ambicka

,

Krzysztof Małecki

,

Wojciech H. Wysocki

,

Jerzy Mituś

,

Janusz Ryś